Table 4

SOs are effective for prevention and treatment of cancer in vivo

TriterpenoidCancer ModelTreatment or PreventionCombinationReference
CDDO-ImSyngeneic L1210 leukemia and B16 melanoma modelsTreatmentNonePlace et al., 2003
CDDOXenograft of MDA-MB-435 ER-breast cancer cellsTreatmentNoneLapillonne et al., 2003
CDDO-ImXenograft of MDA-MB-468 ER-breast cancer cellsTreatmentTRAILHyer et al., 2005
CDDO-ImLiver carcinogenesis induced by aflatoxin in ratsPreventionNoneYates et al., 2006
Liposomal
CDDO		Xenograft of MCF7 ER + breast cancer cells stably overexpressing HER2TreatmentNoneKonopleva et al., 2006
CDDO-ImPlasmacytomas in iMycEμ transgenic miceTreatmentNoneHan et al., 2006
CDDO-Me
CDDO-Ea
CDDO-Ma		Lung carcinogenesis induced by vinyl carbamate in A/J micePreventionNoneLiby et al., 2007a, 2008a
Liposomal
CDDO-Me		4T1/BALB/c model of metastatic breast cancerTreatmentNoneLing et al., 2007
Liposomal
CDDO
CDDO-Im		TRAF2DN/Bcl-2 transgenic mouse model of CLL and small B-cell lymphomaTreatmentNoneKress et al., 2007
CDDO-MeXenograft of Kaposi's sarcoma cellsTreatmentNoneVannini et al., 2007
Liposomal
CDDO-Me		APL cells from hMRP8-PML/RARα transgenic mice propagated into syngenic FVB-N miceTreatmentATRATabe et al., 2007
di-CDDO (TP-225)Skin carcinogenesis induced by UV radiation in “high-risk” hairless micePreventionNoneDinkova-Kostova et al., 2008
CDDO-MeXenograft of Dul45 prostate cancer cells in nude ratsTreatmentNoneHyer et al., 2008
CDDO-MeMMTV-neu model of ER- breast cancerBothLG100268Liby et al., 2008b
CDDO-MeXenograft of PC-3 prostate cancer cellsTreatmentNoneDeeb et al., 2009
CDDO-Me
CDDO-EA		Lung carcinogenesis induced by vinyl carbamate in A/J miceBothLG100268 and NRX194204Liby et al., 2009
CDDO-MeXenograft of MC38 colon cancer cellsTreatmentTumor-associated antigen vaccineNagaraj et al., 2010
CDDO-MeXenograft of L3.6pL human pancreatic cancer cellsTreatmentNoneJutooru et al., 2010
CDDO-Me
CDDO-EA		LSL-KrasG12D/+;LSL-Trp53R127H/+;Pdx-1-Cre mouse model of pancreatic cancerPreventionLG100268Liby et al., 2010
CDDO-ImExperimental metastasis model –B16F1 melanoma and HT-29 colon cancer cells injected into the mesenteric vein metastasize to the liverTreatmentNoneTownson et al., 2011
CDDOTRAMP modelPreventionNoneDeeb et al., 2011
CDDO-Im nanoparticlesOrthotopic injection of primary MMTV-Neu or 4TO7 tumor cells into BALB/c or FVB/NJ miceTreatmentHER-2 DNA vaccineLiao et al., 2011
CDDO-MeBrca1Co/Co;MMTV-Cre;p53+/− transgenic mouse model of BRCA1-mutated breast cancerPreventionNoneKim et al., 2012
CDDO-MePyMT model of ER- breast cancerPreventionNoneTran et al., 2012

  • MMTV, mouse mammary tumor virus; PyMT, polyoma middle T.