Examples of dose, solubility, and volume requirements for a range of poorly water-soluble drugs
| Drug | Dose | Solubility | Volume Required for Complete Solubilization | Absorption |
|---|---|---|---|---|
| mg | mg/ml | ml | ||
| Piroxicam | 20 | 0.007 | 2857 | Low, variable |
| Digoxin | 0.5 | 0.024 | 21 | Good |
| Griseofulvin | 500 | 0.015 | 33,333 | Low, variable |
| Chlorthiazide | 500 | 0.78 | 636 | Reasonable |
From Amidon et al. (1995).