Therapeutic opportunities of ADK manipulation: summary of major findings and new trends
| Goal | Method | Outcome |
|---|---|---|
| Adenosine augmentation | Systemic ADK inhibitors | Seizure suppression |
| Antinociception | ||
| Anti-inflammatory action | ||
| Neuroprotection | ||
| Attenuation of age-related hearing loss | ||
| Antipsychotic-like activity | ||
| Adenosine augmentation | Ketogenic diet | Seizure suppression |
| Adenosine augmentation | Adk−/− stem cell transplantation | Neuroprotection |
| Seizure suppression | ||
| Prevention of epilepsy | ||
| Adenosine augmentation | Anti-ADK gene therapy | Neuroprotection |
| Seizure suppression | ||
| Cell proliferation | ADK inhibitors | Stimulation of β-cell proliferation |
| Parasitology | Prodrug activation via ADK | Parasite toxicity |