TABLE 1

Recommendations for formal receptor nomenclature based on new pairings of class A orphan receptors with cognate ligands

Gene symbols are those approved by the HUGO Gene Nomenclature Committee (http://www.genenames.org/) (Seal et al., 2011). Where the phenotype of the knockout mouse has been published, this is indicated: Further information can be obtained from the IUPHAR Database (http://www.iuphar-db.org/) (Sharman et al., 2011) and the Mouse Genome Database at Mouse Genome Informatics (Eppig et al., 2012).

Endogenous LigandOfficial IUPHAR NomenclaturePrevious NomenclatureApproved Human Gene SymbolKnockout MousePhenotype Reported
Chemerin (RARRES2, resolvin E1, TIG2)ChemerinCMKLR1CMKLR1YesYes
CXCL12 (SDF-1), CXCL11 (ITAC)CXCR7CMKOR1CXCR7YesYes
Omega-3 fatty acidsFFA4GPR120/GPR129O3FAR1YesYes
LactateHCA1GPR81/GPR104HCAR1YesYes
d-β-HydroxybutyrateHCA2GPR109AHCAR2YesYes
3-HydroxyoctanoateHCA3GPR109BHCAR3aNo
LPALPA4GPR23LPAR4YesYes
LPALPA5GPR92/GPR93LPAR5YesYes
LPALPA6P2RY5LPAR6No
2-OxoglutarateOxoglutarateGPR91OXGR1No
SuccinateSuccinateGPR99SUCNR1YesYes
  • a Gene absent in mice.