Naloxonazine-sensitive and -insensitive actions
Compiled from the literature (Pasternak et al., 1980b, 1983; Hahn and Pasternak, 1982; Ling et al., 1983, 1984, 1985, 1986; Munson, 1983; Wood and Pasternak, 1983; Bodnar et al., 1988; Heyman et al., 1988; Mann et al., 1988a,b; Paul and Pasternak, 1988; Paul et al., 1989a; Janik et al., 1992; Pick et al., 1993; Honkanen et al., 1996).
| Morphine Effect | Sensitivity | |
|---|---|---|
| β-Funaltrexamine | Naloxonazine | |
| Analgesia | ||
| Systemic | Yes | Yes |
| Supraspinal | Yes | Yes |
| Spinal | Yes | No |
| Supraspinal/spinal synergy | Yes | No |
| Respiratory depression | Yes | No |
| Inhibition of gastrointestinal transit | Yes | No |
| Prolactin release | Yes | Yes |
| Growth hormone release | Yes | No |
| Physical dependence | Yes | Mixed |
| Feeding | Yes | Yes |
| Nigrostriatal dopamine release | No | |
| Alcohol intake | Yes | |
| Pruritus | No | |