Ligand-promoted desensitization and endocytosis of MAS-related G protein–coupled receptors
MRGPR that have been analyzed for their ligand-induced regulation are listed in conjunction with the respective ligand and expression system used.
| Receptor | Ligand | Desensitization | Endocytosis | System | Reference |
|---|---|---|---|---|---|
| mMRGPRA1 | FLRFamide | YES | YES | HEK293 | Dong et al., 2001 |
| Han et al., 2002 | |||||
| mMRGPRA4 | NPAF | YES | N.D. | HEK293 | Dong et al., 2001 |
| mMRGPRC | γ2-MSH | YES | YES | HEK293, F11, ND-C, Cos7 | Han et al., 2002 |
| BAM8–22 | Solinski et al., 2010 | ||||
| Dyn-14 | |||||
| rMRGPRC | γ2-MSH BAM8–22 | N.D. | YES | HEK293, F11, ND-C | Solinski et al., 2010 |
| hMRGPRD | β-Alanine | N.D. | YES | CHO | Shinohara et al., 2004 |
| rMRGPRD | β-Alanine | N.D. | YES | HEK293 | Milasta et al., 2006 |
| hMRGPRX1 | BAM8–-22 | NO | NO | HEK293, F11, ND-C, Cos7 | Solinski et al., 2010 |
| hMRGPRX2 | Cortistatin-14 | NO | NO | HEK293 | Subramanian et al., 2011a |
| LL-37 | LAD2, HMC-1 |
h, human; m, mouse; N.D., not determined; r, rat.