Drug Pharmacologya | Doses | Route | Strain/Species | Sex | ICSS Procedureb | Drug Effectc | Dependent Measure | Reference | ||
---|---|---|---|---|---|---|---|---|---|---|
Drug Name | Selectivity | Structure | Parameter | |||||||
mg/kg | ||||||||||
Amphetamine | DA/NE>5HT | 0.1–2.0 | i.p. | Sprague-Dawley rat | Male | Free operant | Facilitation | ↑rate | Carey et al., 1974 | |
Amphetamine | DA/NE>5HT | 0.25–2.0 | i.p. | Fischer rat | Male | Discrete trial | Amplitude | Facilitation | ↓CIT | Esposito et al., 1980 |
Amphetamine | DA/NE>5HT | 0.032–1.0 | i.p. | Sprague-Dawley rat | Male | Hybrid | Frequency | Facilitation | ↓θ0 ↑rate | Bauer et al., 2013b |
Amphetamine | DA/NE>5HT | 1.0–4.0 | i.p. | C57Bl6/J mouse | Male | Hybrid | Frequency | Facilitation | ↓M50 | Elmer et al., 2010 |
Amphetamine | DA/NE>5HT | 1.0–4.0 | i.p. | DBA/2J mouse | Male | Hybrid | Frequency | Facilitation | ↓M50 | Elmer et al., 2010 |
(+)-Phenmetrazine | DA/NE>5HT | 0.32–10 | i.p. | Sprague-Dawley rat | Male | Hybrid | Frequency | Facilitation | ↓θ0 ↑rate | Bauer et al., 2013b |
m-Fluroamphetamine | DA/NE>5HT | 1.0–3.2 | i.p. | Sprague-Dawley rat | Male | Hybrid | Frequency | Facilitation | ↓θ0 ↑rate | Bauer et al., 2013b |
(+)-Methamphetamine | DA/NE>5HT | 0.032–1.0 | i.p. | Sprague-Dawley rat | Male | Hybrid | Frequency | Facilitation | ↓θ0 ↑rate | Bauer et al., 2013b |
(±)Methcathinone | DA/NE>5HT | 0.1–1.0 | i.p. | Sprague-Dawley rat | Male | Hybrid | Frequency | Facilitation | ↑rate | Bonano et al., 2014 |
PAL-314 | DA/NE>5HT | 0.32–10 | i.p. | Sprague-Dawley rat | Male | Hybrid | Frequency | Mixed | ↓θ0 ↑↓rate | Bauer et al., 2013b |
PAL-313 | DA/NE/5HT | 0.32–3.2 | i.p. | Sprague-Dawley rat | Male | Hybrid | Frequency | Mixed | ↓θ0 ↑↓rate | Bauer et al., 2013b |
(+)MDMA | DA/NE/5HT | 0.1–3.2 | i.p. | Sprague-Dawley rat | Male | Hybrid | Frequency | Mixed | ↓θ0 ↑↓rate | Bauer et al., 2013b |
PAL-287 | DA/NE/5HT | 0.32–10 | i.p. | Sprague-Dawley rat | Male | Hybrid | Frequency | Mixed | ↓θ0 ↑↓rate | Bauer et al., 2013b |
(−)MDMA | DA<NE/5HT | 0.32–3.2 | i.p. | Sprague-Dawley rat | Male | Hybrid | Frequency | Mixed | ↑↓rate | Bauer et al., 2013b |
(±)Methylone | DA/NE/5HT | 1.0–10 | i.p. | Sprague-Dawley rat | Male | Hybrid | Frequency | Mixed | ↑↓rate | Bonano et al., 2014 |
(±)Mephedrone | DA/NE/5HT | 1.0–10 | i.p. | Sprague-Dawley rat | Male | Hybrid | Frequency | Mixed | ↑↓rate | Bonano et al., 2014 |
(±)Mephedrone | DA/NE/5HT | 1.0–10 | i.p. | C57Bl6/J mouse | Male | Hybrid | Frequency | Mixed | ↓θ0 ↓EF50 | Robinson et al., 2012 |
PAL-544 | DA/NE/5HT | 0.32–3.2 | i.p. | Sprague-Dawley rat | Male | Hybrid | Frequency | Mixed | ↑↓rate | Banks et al., 2014 |
PAL-571 | DA/NE/5HT | 0.32–3.2 | i.p. | Sprague-Dawley rat | Male | Hybrid | Frequency | Mixed | ↑↓rate | Banks et al., 2014 |
PAL-569 | DA<NE/5HT | 0.32–3.2 | i.p. | Sprague-Dawley rat | Male | Hybrid | Frequency | Depression | ↓rate | Banks et al., 2014 |
PAL-542 | DA/5HT>NE | 0.32–3.2 | i.p. | Sprague-Dawley rat | Male | Hybrid | Frequency | Depression | ↓rate | Banks et al., 2014 |
Fenfluramine | DA<5HT/NE | 0.32–3.2 | i.p. | Sprague-Dawley rat | Male | Hybrid | Frequency | Depression | ↓rate | Bauer et al., 2013b |
Fenfluramine | DA<5HT/NE | 20 | i.p. | Sprague-Dawley rat | Male | Free operant | Depression | ↓rate | Olds, 1995 |
Rate, response rate; CIT, current-intensity threshold; θ0: theta-0 threshold; M50 or EF50, frequency maintaining 50% maximum rate.
↵a Selectivity for monoamine release.
↵b First colunn indicates structure of experimental session (see text for details). Second column indicates stimulation parameter under manipulation across trials.
↵c Most prominent drug effect on ICSS.