Drug Pharmacologya | Doses | Route | Strain/Species | Sex | ICSS Procedureb | Drug Effectc | Dependent Measure | Reference | ||
---|---|---|---|---|---|---|---|---|---|---|
Drug Name | Selectivity | Structure | Parameter | |||||||
mg/kg | ||||||||||
Apomorphine | D1/D2 | 0.03–0.3 | s.c. | Sprague-Dawley rat | Male | Hybrid | Frequency | Mixed | ↑↓rate | Depoortere et al., 1996 |
Apomorphine | D1/D2 | 0.1 | s.c. | Wistar rat | Male | Hybrid | Amplitude | Depression | ↓rate | Strecker et al., 1982 |
SKF81297 | D1 | 0.125–1.5 | s.c. | Wistar rat | Male | Discrete trial | Amplitude | Depression | ↑CIT | Baldo et al., 1999 |
SKF81297 | D1 | 0.1–10 | i.p. | Swiss-Webster mouse | Male | Hybrid | Frequency | No effect | Malanga et al., 2008 | |
SKF81297 | D1 | 0.1–10 | i.p. | Swiss-Webster mouse | Female | Hybrid | Frequency | No effect | Malanga et al., 2008 | |
SKF82958 | D1 | 0.03–0.3 | i.p. | Swiss-Webster mouse | Male | Hybrid | Frequency | Facilitation | ↓M50 | Gilliss et al., 2002 |
Quinpirole | D2 | 0.03–1.0 | i.p. | Sprague-Dawley rat | Male | Hybrid | Frequency | Mixed | ↑↓rate | Depoortere et al., 1996 |
Quinpirole | D2 | 0.1–10 | i.p. | Swiss-Webster mouse | Male | Hybrid | Frequency | Mixed | ↑↓θ0 | Malanga et al., 2008 |
Quinpirole | D2 | 0.1–10 | i.p. | Swiss-Webster mouse | Female | Hybrid | Frequency | Mixed | ↑↓θ0 | Malanga et al., 2008 |
Quinpirole | D2 | 0.5–2.0 | i.p. | Long Evans rat | Male | Hybrid | Frequency | Mixed | ↓1/4 threshold | Nakajima and O’Regan, 1991 |
Rate, response rate; CIT, current-intensity threshold; θ0, theta-0 threshold; M50, EF50, or LOR, frequency maintaining 50% maximum rate; 1/4 threshold, frequency maintaining 25% maximum rate.
↵a Dopamine receptor subtype selectivity
↵b First column indicates structure of experimental session (see text for details). Second column indicates stimulation parameter under manipulation across trials.
↵c Most prominent drug effect on ICSS.