Effect of major risk factors on ischemia/reperfusion (I/R) injury as well as pre-, post-, and remote conditioning in the majority of the studies
| Risk Factor | I/R Injury | Preconditioning | Postconditioning | Remote Conditioning |
|---|---|---|---|---|
| Aging | ↑ | ↓ | ↓ | — CL |
| Hypertension, hypertrophy, and remodeling | — | — | ↓ | N.D. |
| Hyperlipidemia | ↑ | ↓ CL | ↓ | N.D. |
| Diabetes | ↑ | ↓ CL | ↓ | ↓CL |
| Uremia, kidney failure | ↑ | — | — | N.D. |
| Impaired coronary microcirculation | ↑ | —↑ | ↓ | N.D. |
CL, some clinical data are also available; N.D., no data available; ↑, enhance; ↓, attenuate, —, no effect.