IC50 Amiloride Inhibitiona | Na+/K+ Permeability Ratio | pH50 Activation | pHD50 Steady-State Desensitization | Desensitization Time Constant (at pH Close to pH50) | Most Important Sites of Expression | |
---|---|---|---|---|---|---|
μM | s | |||||
ASIC1a | 10 | 6–13 | 6.2–6.6 | ∼7.2 | ∼0.4 | CNS, PNS |
ASIC1b | 21 | ∼3 | 5.9–6.3 | ∼6.7 | ∼0.9 | PNS |
ASIC2a | 28 | ∼10 | 4.0–4.9 | ∼5.6 | ∼1.4 | CNS, PNS |
ASIC3 | 60–100 | ∼12 | 6.4–6.7 | ∼7.1 | ∼0.3 | PNS |
ENaCαβγ | 0.1 | ≥100 | N.A. | N.A. | N.A. | Kidney, colon, lung |
N.A., not applicable; pHD50, pH of half-maximal desensitization.
↵a For transient ASIC current component.