Proposed new nomenclature for Adhesion GPCRs
| Subfamily | Receptor | |||
|---|---|---|---|---|
| Current Number | Proposed New Name | Current Gene Name | Current Protein Name (Alternative Names) | Proposed New Name |
| I | L (Latrophilin) | LPHN1 | Latrophilin 1 (CIRL-1, CL1, LEC2) | ADGRL1 |
| LPHN2 | Latrophilin 2 (CIRL-2, CL2, LPHH1, LEC1) | ADGRL2 | ||
| LPHN3 | Latrophilin 3 (CIRL-3, CL3, LEC3) | ADGRL3 | ||
| ELTD1 | ELTD1 (ETL) | ADGRL4 | ||
| II | E (EGF-TM7) | EMR1 | EMR1 (F4/80) | ADGRE1 |
| EMR2 | EMR2 (CD312) | ADGRE2 | ||
| EMR3 | EMR3 | ADGRE3 | ||
| EMR4 | EMR4 (FIRE, GPR127) | ADGRE4 | ||
| CD97 | CD97 (BL-Ac(F2)) | ADGRE5 | ||
| III | A | GPR123 | GPR123 | ADGRA1 |
| GPR124 | GPR124 (TEM5) | ADGRA2 | ||
| GPR125 | GPR125 | ADGRA3 | ||
| IV | C (CELSR) | CELSR1 | CELSR1 | ADGRC1 |
| CELSR2 | CELSR2 (MEGF3) | ADGRC2 | ||
| CELSR3 | CELSR3 (MEGF2, Fm1, EGFL1) | ADGRC3 | ||
| V | D | GPR133 | GPR133 | ADGRD1 |
| GPR144 | GPR144 | ADGRD2 | ||
| VI | F | GPR110 | GPR110 | ADGRF1 |
| GPR111 | GPR111 | ADGRF2 | ||
| GPR113 | GPR113 | ADGRF3 | ||
| GPR115 | GPR115 | ADGRF4 | ||
| GPR116 | GPR116 (Ig-Hepta) | ADGRF5 | ||
| VII | B (BAI) | BAI1 | BAI1 | ADGRB1 |
| BAI2 | BAI2 | ADGRB2 | ||
| BAI3 | BAI3 | ADGRB3 | ||
| VIII | G | GPR56 | GPR56 (TM7XN1) | ADGRG1 |
| GPR64 | GPR64 (HE6) | ADGRG2 | ||
| GPR97 | GPR97 (Pb99) | ADGRG3 | ||
| GPR112 | GPR112 | ADGRG4 | ||
| GPR114 | GPR114 | ADGRG5 | ||
| GPR126 | GPR126 (VIGR, DREG) | ADGRG6 | ||
| GPR128 | GPR128 | ADGRG7 | ||
| IX | V | GPR98 | VLGR1 (GPR98, MASS1, USH2C, FEB4) | ADGRV1 |
BAI, brain-specific angiogenesis inhibitor; CD, cluster of differentiation; CELSR, cadherin EGF LAG seven-pass G-type receptor; CIRL, calcium-independent receptor of α-latrotoxin; CL, CIRL/latrophilin; DREG, developmentally regulated GPCR; EGFL, epidermal growth factor–like; EGF-TM7, epidermal growth factor–seven-span transmembrane; ELTD, EGF, latrophilin and seven transmembrane domain–containing protein; EMR, EGF-like molecule containing mucin-like hormone receptor; ETL, EGF-TM7-latrophilin–related protein; FEB, febrile seizures gene disease locus; FIRE, F4/80-like receptor; Fm, Flamingo; HE, human epididymal; LEC, lectomedin; LPHH, latrophilin homolog in humans; MASS, monogenic audiogenic seizure susceptibility; MEGF, multiple epidermal growth factor–like domains; TEM, tumor endothelial marker; VIGR, vascular inducible GPCR; VLGR, very large GPCR.