Distribution of UT mRNA and UII binding sites on the rat brain

The distribution of 125I-labeled UII binding sites has been described in three reports: 1) Maguire et al., 2000; 2) Clark et al., 2001; 3) Jégou et al., 2006. [Reprinted from Jégou et. al. (2006). Used with permission.]

StructureGPR14 mRNAUII Binding Sites
 Cingulate cortex+/++
 Insular cortex+
 Orbital cortex+
 Retrosplenial cortex+
 Entorhrinal cortex++/+++
Olfactory system
 Main olfactory bulb
  Mitral cell layer++
  Internal granular layer++
  Glomerular layer+
 Anterior olfactory nucleus++
 Dorsal endopiriform nucleus++Yes (2, 3)
 Piriform cortex+++/++++
 Tenia tecta+++
 Olfactory tubercle+++
Basal ganglia
 Caudate putamen+/−
 Globus pallidus
 Accumbens nucleus+/−Yes (2)
 Ventral pallidum+/−
 Islands of Calleja
 Substantia nigra
  Pars compacta++
  Pars reticularis
 Subthalamic nucleus+/++
 Ventral tegmental area+Yes (2)
 Lateral septal nucleus, dosal+Yes (2, 3)
 Lateral septal nucleus, intermediate+
 Lateral septal nucleus, ventral+
 Horizontal limb of the diagonal band of Broca+
Hippocampal formation
 Ammon’s horn
  Stratum oriensPatchy labeling
  Pyramidal cell layer+++/++++
  Stratum radiatumPatchy labeling
 Dentate gyrus+++/++++
 Subiculum complex++Yes (2)
 Nucleus of the lateral olfactory tract+++
 Bed nucleus of the accessory olfactory tract+++
 Anterior cortical amygdaloid nucleus+++
 Posterolateral cortical amygdaloid nucleus+++
 Posteromedìal cortical amygdaloid nucleus++
 Amygdalopiriform transition area++
 Medial amygdaloid nucleus+++Yes (3)
 Posteromedial amygdalohippocampal transition area+++
 Basolatetal amygdaloid complex++
 Basomedial amygdaloid complex++
 Central amygdaloid complex++
 Bed nucleus of the stria terminalis, lateral+Yes (2, 3)
Visual system
 Parabigeminal nucleus+++Yes (3)
 Lateral geniculate nuclei, ventral and dorsal+/−Yes (2, 3)
 Pretectum+Yes (3)
 Superior colliculus+
 Pineal gland++++
 Habenular nucleus
  Medial+++Yes (2)
 Paraventricular thalamic nucleus++
 Anterodorsal thalamic nucleus++
 Anteroventral thalamic nucleus+/++Yes (2, 3)
 Centromedian thalamic nucleus+
 Reticular thalamic nucleus+
 Mediodorsal thalamic nucleus+
 Reuniens thalamic nucleus+
 Rhomboid nucleus+
 Ventrolatetal thalamic nucleus+
 Ventroposterior lateral thalamic nucleus+
 Ventroposterior medial thalamic nucleus+
 Ventromedial thalamic nucleus+
 Posterior thalamic nuclear group+
 Paratenial thalamic nucleus+
Zona incerta++
 Anterior hypothalamic area, anterior+
 Anterior hypothalamic area, posterior++
 Anterior medial preoptic nucleus
 Anteroventral preoptic nucleus
 Medial preoptic area
 Medial preoptic nucleus+/++Yes (2)
 Lateral preoptic area
 Median preoptic nucleus++
 Lateroanterior hypothalamic nucleus+
 Magnocellular preoptic nucleus
 Supachiasmatic nucleus++
 Supraoptic nucleus+++
 Ventromedial hypothalamic nucleus+++
 Lateral hypothalamic area+
 Posterior hypothalamic area+
 Dorsomedian hypothalamus, dorsal+
 Paraventricular nucleus, magnocellular part++
 Paraventricular nucleus, median parvocellular+
 Arcuate nucleus+++/++++
 Mammillary nucleus, medial, lateral++
Circumventricular organs
 Area postrema+++
 Choroid plexus++++
Reticular formation
 Paramedian reticular nucleusPatchy Labeling
 Medullary nucleus, ventral, dorsal
  VentralPatchy Labeling
 Lateral paragigantocellular nucleusPatchy Labeling
 Rostroventrolateral reticular nucleus++
 Dorsal paragigantocellular nucleus
 Gigantocellular reticular nucleusPatchy Labeling
  VentralPatchy Labeling
  AlphaPatchy Labeling
 Intermediate reticular nucleus+
 Parvocellular reticular nucleusPatchy Labeling
 Pontine reticular nucleiPatchy Labeling
 Periaqueducal gray+
 Cuneiform nucleus+
 Dorsal tegmental nucleus+++
 Ventral tegmental nucleus+++
 Laterodorsal tegmental nucleus+++Yes (2)
 Microcellular tegmental nucleus
 Pedunculopontine tegmental nucleus+/−Yes (2, 3)
 Deep mesencephalic nucleus
Raphe complex
 Dorsal raphe nucleus++
 Median raphe nucleus++
 Raphe pallidus nucleus++
Interpeduncular nucleus++/+++Yes (2)
Locus coeruleus++++
Brainstem nuclei associated to autonomic functions
 Nucleus of the solitary tract+++
 Dorsal motor nucleus of the vagus+++/++++
 Ambiguus nucleus+++
 Parabrachial nucleus
Motor nuclei
 Oculomotor nucleus++
 Trochlear nucleus++
 Trigeminal nucleus++++
 Abducens nucleus+++Yes (1)
 Facial nucleus+++/++++
 Hypoglossal nucleus+++
Somatosensory system
 Mesencephalic trigeminal nucleus++++
 Principal sensory nucleus, dorsomedial++/+++
 Nucleus of the spinal tract
  Interpolar part+
 External cuneate nucleus++
 Cuneate nucleus
 Paratrigeminal nucleus++
Auditory system
 Lateral superior olive++
 Medial superior olive++++
 Medioventral periolivary nucleus++++
 Lateroventral periolivary nucleus+++
 Nucleus of the trapezoid body++++
 Dorsal cochlear nucleus++
 Ventral cochlear nucleus
 Ventral nucleus of the lateral lemniscus+/++
 Inferior colliculus+
 Medial geniculate body+
Vestibular system
 Superior vestibular nucleus+
 Lateral vestibular nucleus+
 Medial vestibular nucleus++
 Prepositus hypoglossal nucleus++
Supragenuate nucleus+++
Precerebellar nuclei
 Pontine nuclei++++Yes (2, 3)
 Reticulotegmental nucleus of the pons++
 Inferior olivary complex+++
 Lateral reticular nucleus++
Red nucleus
 Purkinje cell layer++++Yes (3)
 Granular layer++++
 Molecular layer
 Medial cerebellar nucleus+/++
 Interposed cerebellar nucleus+/++
 Lateral cerebellar nucleus+/++
Spinal cord
 Layer 2–4++
 Layer 5+
 Layer 7–8++
 Layer 9+++
 Layer 10++/+++
  • The symbols provide a semiquantitative evaluation of the density of UT mRNA: ++++, very high density; +++, high density; ++, moderate density; +, low density; —, no hybridization signal.