TABLE 2

α7 nAChR agonists entered clinical trials and in discovery phase

CompoundsTherapeutic IndicationsDevelopment StatusCompanyReference
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GTS-21Alzheimer’s diseasePhase 2ComentisBriggs et al., 1995; Azuma et al., 1996, 1999; Mahnir et al., 1998; Li et al., 1999; Adams et al., 2000; Crutcher, 2000; Bruchfeld et al., 2010; Loram et al., 2010; Vukelic et al., 2013
Cognitive deficiency in schizophrenia
Parkinson’s disease
Smoking cessation
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TropisetronAlzheimer’s diseasePhase 2Papke et al., 2005; Ishikawa and Hashimoto, 2011; Stegemann et al., 2013
Cognitive deficiency in schizophrenia
Pain
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PNU-282987Alzheimer’s diseasePhase 1PfizerBodnar et al., 2005; Hajós et al., 2005
Cognitive deficiency in schizophrenia
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SSR-180711Alzheimer’s diseaseDiscoverySanofiBiton et al., 2007; Pichat et al., 2007; O'Donnell et al., 2009
Cognitive deficiency in schizophrenia
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ABT-126Alzheimer’s diseasePhase 2AbbVieGault et al., 2015
Cognitive deficiency in schizophrenia
Pain
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Encenicline (EVP-6124)Alzheimer’s diseasePhase 2 and 3ForumPrickaerts et al., 2012; Barbier et al., 2015; Huang et al., 2014a; Preskorn et al., 2014; Keefe et al., 2015
Cognitive deficiency in schizophrenia
Smoking cessation
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MEM3454/RG3487Alzheimer’s diseasePhase 2Memory/RocheRezvani et al., 2009; Wallace et al., 2011; Huang et al., 2014b; Umbricht et al., 2014
Cognitive deficiency in schizophrenia
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TC-5619Alzheimer’s diseasePhase 2TargaceptHauser et al., 2009; Mazurov et al., 2012; Lieberman et al., 2013; Walling et al., 2015
Cognitive deficiency in schizophrenia
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JN403Alzheimer’s diseaseDiscoveryNovartisFeuerbach et al., 2007, 2009; Enz et al., 2009; Jiang et al., 2009; Arias et al., 2013
Cognitive deficiency in schizophrenia
Pain
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SEN34625/WYE-103914Alzheimer’s diseaseDiscoveryWeythGhiron et al., 2010; Marquis et al., 2011
Cognitive deficiency in schizophrenia
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AQW051Alzheimer’s diseasePhase 2NovartisDi Paolo et al., 2014; Feuerbach et al., 2015
Cognitive deficiency in schizophrenia
L-DOPA induced dyskinesias