TABLE 4

α7 nAChR positive allosteric modulators

CompoundsTherapeutic IndicationsModulator TypeCompanyReference
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XY4083Alzheimer’s diseaseIXYTisNg et al., 2007
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PNU-120596Alzheimer’s diseaseIIPfizerHurst et al., 2005; Barron et al., 2009; Young et al., 2008; Young and Geyer, 2013
Cognitive deficiency in schizophrenia
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NS-1738Alzheimer’s diseaseINeurosearchTimmermann et al., 2007; Thomsen and Mikkelsen, 2012
Cognitive deficiency in schizophrenia
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A-867744Alzheimer’s diseaseIIAbbVieMalysz et al., 2009, 2010
Cognitive deficiency in schizophrenia
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LY-1078733Alzheimer’s diseaseIIEli LillyBroad et al., 2006
Cognitive deficiency in schizophrenia
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RO5126946Alzheimer’s diseaseDiscoveryRocheSahdeo et al., 2014