Glucuronide metabolites that are metabolized by CYP2C8
| Substrate | Metabolic pathway catalyzed by CYP2C8 | Other CYP enzymes involved in overall metabolism | References |
|---|---|---|---|
| Clopidogrel acyl 1-β-d-glucuronidea | Tornio et al., 2014 | ||
| Desloratadine N-glucuronide | 3-hydroxylation | Kazmi et al., 2015 | |
| Diclofenac acyl glucuronide | 4′-hydroxylation | Kumar et al., 2002 | |
| Estradiol-17β-glucuronide | 2-hydroxylation | CYP3A7 | Delaforge et al., 2005 |
| Gemfibrozil 1-O-β glucuronide | Benzylic oxidation | Ogilvie et al., 2006; Baer et al., 2009 | |
| Licofelone 1-O-acyl glucuronide (M1) | Hydroxylation (M3) | Albrecht et al., 2008 | |
| Lu AA34893 carbamoyl glucuronidea | Kazmi et al., 2010 | ||
| MRL-C acyl glucuronide | Hydroxylation | CYP3A4 | Kochansky et al., 2005 |
| Sipoglitazar β-1-O-acyl glucuronide | O-dealkylation (M-I) | Nishihara et al., 2012 |
MRL-C, 2-[[5,7-dipropyl-3-(trifluoromethyl)-1,2-benzisoxazol-6-yl]oxy]-2-methylpropanoic acid.
↵a These glucuronides are likely to be substrates of CYP2C8 based on their metabolism-dependent inhibitory effect on CYP2C8.