Summary of phenotype of rats with genetic alterations of the endothelin system
| Animal Model | Site (Cre) | Phenotype | References |
|---|---|---|---|
| TGR(hET-2)37 | Whole body ET-2 overexpression | males: lower body weight, interstitial and glomerularsclerosis | Liefeldt et al., 1995, 1999 |
| females: glomerularsclerosis | Liefeldt et al., 1999 | ||
| Homozygous spotting lethal (sl/sl) | Whole body, natural mutation in the ETB | aganglionic megacolon; white coat color; death at an early age. | Gariepy et al., 1996 |
| DβH-ETB:ETBsl/sl | ETB deficient except for nerves (insertion with dopamine-β-hydroxylase promoter) | ETB expressed in nerves but absent elsewhere; coat color spotting; salt-sensitive hypertension | Gariepy et al., 1998; Gariepy et al., 2000; Pollock et al., 2000 |