Published studies of drugs that were not tested in both animal and human laboratories
Symbols indicate that the studies were interpreted as providing positive (+) or negative (−) results regarding the suitability of the drug as a pharmacotherapy. Under Laboratory Animal Studies, studies using rodent subjects are indicated by italics.
| Drug | Animal Laboratory Studies | Human Laboratory Studies | Clinical Trials |
|---|---|---|---|
| Citalopram | (−)Howell et al., 2007 | none | (+)Moeller et al., 2007 |
| (−)Hiranita et al., 2009 | |||
| Bupropion | none | (+)Stoops et al., 2012b | (−)Shoptaw et al., 2008 |
| Disulfiram | none | (−)Haile et al., 2012 | (+)Carroll et al., 2004 |
| Fluoxetine | (−)Carroll et al., 1990 | none | (−)Grabowski et al., 1995 |
| (−)Kleven and Woolverton, 1993 | (−)Batki et al., 1996 | ||
| (−)Howell et al., 2007 | |||
| Gabapentin | none | (−)Hart et al., 2004 | (−)Berger et al., 2005 |
| (−)Hart et al., 2007a | (−)Bisaga et al., 2006 | ||
| (−)Hart et al., 2007b | |||
| Gepirone | (−)Gold and Balster, 1992 | none | (−)Jenkins et al., 1992 |
| Lisdexamfetamine | (+)Banks et al., 2015 | none | (−)Mooney et al., 2015 |
| Lithium | (+)Woolverton and Balster, 1979 | none | (−)Gawin et al., 1989 |
| Mazindol | (−)Kleven and Woolverton, 1993 | none | (−)Stine et al., 1995 |
| (−)Mansbach and Balster, 1993 | |||
| Methamphetamine | (+)Negus et al., 2007 | none | (+)Mooney et al., 2009 |
| (−)Banks et al., 2011 | |||
| (+)Kohut et al., 2015 | |||
| Naltrexone | (+)Mello et al., 1990b | none | (−)Schmitz et al., 2001 |
| (−)Hemby et al., 1996 | (+)Schmitz et al., 2014 | ||
| (−)Stromberg et al., 2002 | |||
| Pergolide | none | (−)Haney et al., 1998 | (−)Focchi et al., 2005 |
| (−)Malcolm et al., 2000 | |||
| Phenytoin | none | (−)Sofuoglu et al., 1999 | (+)Crosby et al., 1996 |
| Propranolol | (−)Goldberg and Gonzalez, 1976 | none | (−)Kampman et al., 2001 |
| Quetiapine | (−)Brutcher and Nader, 2015 | none | (−)Tapp et al., 2015 |
| Ritanserin | (+)Meert et al., 1991 | none | (−)Johnson et al., 1997 |
| (−)Howell and Byrd, 1995 | (−)Cornish et al., 2001 | ||
| Sertraline | (−)Kleven and Woolverton, 1993 | none | (−)Winhusen et al., 2005 |
| Varenicline | (−)Gould et al., 2011 | none | (+)Plebani et al., 2012 |
| Venlafaxine | none | (−)Foltin et al., 2003 | (−)Ciraulo et al., 2005 |