TABLE 6
1,2,5-thiadiazolidin-3-one 1,dioxide derivatives blocking human PR3 activity
 | kobs/[I] | |||
|---|---|---|---|---|
| PR3 | Elastase | |||
| M−1s−1 | ||||
| R1 | R2 | L | ||
| Isobutyl | (m-COOCH3)Bzl | SO2Ph | 7080 | 63,600 |
| Isobutyl | (m-COCH)Bzl | SO2Ph | 10,300 | 38,700 |
| Isobutyl | Benzyl | SO2(p-Cl phenyl) | 16,200 | 219,000 |
| Isobutyl | Benzyl | SO2CH2(p-Cl phenyl) | 20,300 | 165,000 |
Values are from Groutas et al. (1998).