TABLE 2

Ionotropic GluR pharmacology

Receptor System/DrugDrugActionDeliveryEffectReference
AMPA/kainate
 CocaineCNQXCompetitive antagonistSystemicInhibited cue-induced reinstatementBäckström and Hyytiä, 2003
NBQXAntagonistSystemicInhibited cue-induced reinstatementZavala et al., 2008
DNQXAntagonistSystemicInhibited CPPKaddis et al., 1995
CNQXCompetitive antagonistNAcoreInhibited sensitized locomotor responsePierce et al., 1996
CNQXCompetitive antagonistNAcoreInhibited cocaine intakeSuto et al., 2009
CNQXCompetitive antagonistNAcoreInhibited cocaine intake in extended accessDoyle et al., 2014
CNQXCompetitive antagonistNAcoreInhibited cue-induced reinstatementBäckström and Hyytiä, 2007
CNQXCompetitive antagonistNAcoreInhibited context-induced reinstatementXie et al., 2012
CNQXCompetitive antagonistNAcoreInhibited drug-primed reinstatementCornish and Kalivas 2000
LY293558GluR5 AMPA/kainate antagonistNAcoreInhibited cue-induced reinstatementDi Ciano and Everitt, 2001
AMPAAgonistNAshellPromoted cocaine seekingPing et al., 2008
NaspmAntagonist of GluA2-lacking AMPANAcore / NAshellInhibited incubation of cocaine cravingConrad et al., 2008
 OpiatesCNQXCompetitive antagonistNAcoreInhibited cue-induced and drug-primed reinstatementLalumiere and Kalivas, 2008
 EthanolCNQXCompetitive antagonistSystemicInhibited cue-induced reinstatementBäckström and Hyytiä, 2004
 AmphetaminesDNQXAntagonistSystemicInhibited CPPMiyatake et al., 2005
 DNQXAntagonistSystemicInhibited sensitized locomoter responseKarler et al., 1991
CNQXCompetitive antagonistAccumbensInhibited sensitized locomoter responseBurns et al., 1994
NMDA
 CocaineMK-801Uncompetitive antagonistSystemicInhibited drug-primed CPPBrown et al., 2008
MK-801Uncompetitive antagonistSystemicPromoted drug-primed reinstatementDe Vries et al., 1998
AcamprosateNMDA antagonist, GABA receptor agonistSystemicInhibited cue-induced and drug-primed reinstatementBowers et al., 2007
AcamprosateNMDA antagonist, GABA receptor agonistSystemicInhibited CPPMcGeehan and Olive, 2003a
AcamprosateNMDA antagonist, GABA receptor agonistSystemicInhibited reinstatement of CPPMcGeehan and Olive, 2006
MemantineAntagonistSystemicInhibited CPPKotlińska and Biała, 2000
AP5Competitive antagonistNAcoreInhibited sensitized locomoter responsePulvirenti et al., 1994
AP5Competitive antagonistNAcore/NAshellPromoted cocaine-conditioned locomotionRodríguez-Borrero et al., 2006
AP5Competitive antagonistNAcore/NAshellPromoted cocaine seekingFamous et al., 2007
AP5Competitive antagonistNAcoreInhibited cue-induced reinstatementBäckström and Hyytiä, 2007
 NicotineMK-801Uncompetitive antagonistSystemicInhibited sensitized locomoter responseShoaib and Stolerman, 1992
 AcamprosateNMDA antagonist, GABA receptor agonistSystemicInhibited cue-induced reinstatementPechnick et al., 2011
 MemantineAntagonistSystemicInhibited intakeBlokhina et al., 2005
 OpiatesAcamprosateNMDA antagonist, GABA receptor agonistSystemicInhibited sensitized locomoter responseSpanagel et al., 1998
 MemantineAntagonistSystemicInhibited CPPRibeiro Do Couto et al., 2004
 IfenprodilAntagonist of GluN2B-containing receptorsSystemicInhibited cue-induced and drug-primed reinstatementShen et al., 2011
 IfenprodilAntagonist of GluN2B-containing receptorsSystemicInhibited CPPSuzuki et al., 1999
 IfenprodilAntagonist of GluN2B-containing receptorsNAcoreInhibited cue-induced and drug-primed reinstatementShen et al., 2011
 EthanolAcamprosateNMDA antagonist, GABA receptor agonistSystemicInhibited CPPMcGeehan and Olive, 2003a
 AcamprosateNMDA antagonist, GABA receptor agonistSystemicInhibited intake and CPPOlive et al., 2002
 AP5Competitive antagonistAccumbensInhibited intakeRassnick et al., 1992
 AmphetaminesMK-801Uncompetitive antagonistSystemicInhibited CPPTzschentke, 2007
 IfenprodilAntagonist of GluN2B-containing receptorsSystemicInhibited CPPMiyatake et al., 2005
AP5Competitive antagonistAccumbensDecreased potentiation of conditioned reinforcementBurns et al., 1994