TABLE 3

mGluR pharmacology

DrugActionDeliveryEffectReference
Group I (mGluR1/5)
 CocaineJNJ-16259685mGluR1 NAMSystemicInhibited sensitized locomoter responseDravolina et al., 2006
JNJ-16259685mGluR1 NAMSystemicInhibited intakeAchat-Mendes et al., 2012
MPEP and MTEPmGluR5 NAMSystemicInhibited cue-induced and drug-primed reinstatementKumaresan et al., 2009
FenobammGluR5 NAMSystemicInhibited intake, cue-induced and drug-primed reinstatementKeck et al., 2013
MFZ 10-7mGluR5 antagonistSystemicInhibited intake, cue-induced and drug-primed reinstatementKeck et al., 2014
MPEPmGluR5 NAMSystemicInhibited intakeTessari et al., 2004
MPEPmGluR5 NAMSystemicInhibited CPPMcGeehan and Olive, 2003b
SYN119mGluR1 PAMNAcoreInhibited incubation of cocaine cravingLoweth et al., 2014
Ro67-7476mGluR1 PAMNAcoreInhibited incubation of cocaine cravingLoweth et al., 2014
JNJ-16259685mGluR1 NAMNAcoreInhibited context-primed reinstatementXie et al., 2012
MTEPmGluR5 NAMNAcoreInhibited cue-induced and context-primed reinstatementKnacksted et al., 2013
MPEPmGluR5 NAMNAshellInhibited cocaine context-induced locomotionMartínez-Rivera et al., 2013
MPEPmGluR5 NAMNAshellInhibited drug-primed reinstatementKumaresan et al., 2009
CHPGmGluR5 agonistNAcorePromoted cocaine-seeking cue-induced reinstatementWang et al., 2013
DHPGmGluR1/5 agonistNAcorePromoted cocaine seekingSchmidt et al., 2015
DHPGmGluR1/5 agonistNAshellPromoted cocaine seekingSchmidt et al., 2013
DHPGmGluR1/5 agonistNAcoreInhibited cocaine seeking after incubationLoweth et al., 2014
 NicotineMPEPmGluR5 NAMSystemicInhibited intake and drug-primed reinstatementTessari et al., 2004
 OpiatesMPEPmGluR5 NAMSystemicInhibited CPPPopik and Wróbel, 2002
 EthanolJNJ-16259685mGluR1 NAMNAshellInhibited intakeLum et al., 2014
 MTEPmGluR5 NAMNAcoreInhibited cue-induced reinstatementSinclair et al., 2012
 
 AmphetaminesJNJ-16259685mGluR1 NAMSystemicInhibited intakeAchat-Mendes et al., 2012
 FenobammGluR5 NAMSystemicInhibited cue-induced and drug-primed reinstatementWatterson et al., 2013
MPEPmGluR5 NAMSystemicInhibited CPPMiyatake et al., 2005
Group II (mGluR2/3)
 CocaineLY379268mGluR2/3 agonistSystemicInhibited cue-induced reinstatementCannella et al., 2013
 LY379268mGluR2/3 agonistNAcoreInhibited drug-primed reinstatementPeters and Kalivas, 2006
 
 NicotineLY379268mGluR2/3 agonistSystemicInhibited cue- and context-induced reinstatementLiechti et al., 2007
LY379268mGluR2/3 agonistNAshellInhibited cue-induced reinstatementLiechti et al., 2007
 AZD8529mGluR2 PAMSystemicInhibited intake, cue-induced and drug-primed reinstatementJustinova et al., 2015
 OpiatesLY379268mGluR2/3 agonistSystemicInhibited cue-induced reinstatementBossert et al., 2004, 2005
 LY379268mGluR2/3 agonistNAcoreInhibited cue-induced reinstatementBossert et al., 2005
 LY379268mGluR2/3 agonistNAshellInhibited context-induced reinstatementBossert et al., 2006
 EthanolLY379268mGluR2/3 agonistSystemicInhibited stress- and cue-induced reinstatementZhao et al., 2006
 NAcoreInhibited intakeGriffin et al., 2014
 AmphetaminesLY379268mGluR2/3 agonistSystemicInhibited cue-induced and drug-primed reinstatementKufahl et al., 2013
LY379268mGluR2/3 agonistNAcoreInhibited sensitized locomotor responseChi et al., 2006
AZD8529mGluR2 PAMSystemicInhibited cue-induced reinstatementCaprioli et al., 2015
Group III (mGluR7)
 CocaineAMN082AgonistSystemicInhibited intakeLi et al., 2009
 AMN082AgonistNAcore/NAshellInhibited drug-primed reinstatementLi et al., 2010
 NicotineAMN082AgonistNAcore/NAshellInhibited cue-induced reinstatementLi and Markou, 2015
 OpiatesAMN082AgonistSystemicInhibited drug-primed reinstatementLi et al., 2013
 EthanolAMN082AgonistSystemicInhibited intakeSalling et al., 2008
 AMN082AgonistSystemicInhibited drug-primed CPPBahi et al., 2012

  • CHPG, 2-chloro-5-hydroxyphenylglycine; DHPG, (S)-3,5-dihydroxyphenylglycine; NAM, negative allosteric modulator; PAM, positive allosteric modulator.