TABLE 3

Peptidic GLP-1R agonists that have been launched or are in late-stage clinical trials

AnalogDescriptionCompanyDosing RegimenStatus
ExenatideExendin-4Amylin/Eli Lilly; AstraZenecaTwice dailyLaunched
Exenatide once weeklyExendin-4Amylin/Alkermes/Eli Lilly; AstraZenecaOnce weeklyLaunched
LixisenatideExendin-4 analogSanofi-AventisOnce dailyLaunched
LiraglutideGLP-1 analog linked with a fatty acidNovo NordiskOnce dailyLaunched
AlbiglutideGLP-1 analog fused to albuminGlaxoSmithKlineOnce weeklyLaunched
DulaglutideGLP-1 analog fused to FcEli LillyOnce weeklyLaunched
SemaglutideGLP-1 analog linked with a fatty acidNovo NordiskOnce weeklyPhase 3
Semaglutide (NN9924)GLP-1 analog linked with a fatty di-acidNovo NordiskOralPhase 2
TaspoglutideGLP-1 analog formulated for sustained releaseRocheOnce weeklySuspended