Residues, kinases, and effects of Cx43 phosphorylation
| Assembly/Disassembly Residues | Kinases | Direction of Effect | References |
|---|---|---|---|
| Ser-325,-328,-330 | CK1 | GJs ↑ | Cooper and Lampe (2002) |
| Ser-364,-365 | GJs ↑ | TenBroek et al. (2001), Shah et al. (2002), Yogo et al. (2002), Solan et al. (2007) | |
| Ser-369, -373 | Akt/PKB | GJs ↑ | Shah et al. (2002), Yogo et al. (2002), Park et al. (2007), Dunn and Lampe, (2014) |
| HCs ↑ | Salas et al. (2015) | ||
| Ser-372 | GJs ↑ | Sáez et al. (1997), Yogo et al. (2002), Park et al. (2007), Dunn and Lampe (2014) | |
| Ser-368 | PKC | GJs ↓, ↑ | Sáez et al. (1997), Axelsen et al. (2006), Procida et al. (2009) |
| Tyr-247, -265, -313 | Src, Tyk2 | GJs ↓ | Lin et al. (2001), Ballif et al. (2008), Bonnette et al. (2010), Solan and Lampe (2014), Li et al. (2016) |
| Gating residues | |||
| Ser-255, -279, -282 | MAPK | GJs ↓ | Warn-Cramer et al. (1996) |
| Ser-262 | p34cdc2, MAPK | GJs ↓ | Kanemitsu et al. (1998), Lampe et al. (1998), Doble et al. (2004) |
| Ser-296, 297, 306 | GJs ↑ | Axelsen et al. (2006), Procida et al. (2009) | |
| Ser-368 | PKC | GJs ↓ | Sáez et al. (1997), Axelsen et al. (2006), Procida et al. (2009) |
| HCs ↓ | Bao et al. (2004, 2007), De Vuyst et al. (2007), Hawat and Baroudi (2008) |