Porcn genetic deletion | In vivo (mice) | Porcn gene | Inhibition of WNT3A secretion | n/a | Barrott et al. (2011) |
IWP-1 | In vitro | PORCN protein | Inhibition of WNT secretion (WNT1, -2, and -3A?) | IC50: 58 nM | Chen et al. (2009a) |
| | | | |
IWP-2 | In vitro | PORCN protein | Inhibition of WNT-1, -2, −3a secretion | IC50: 27 nM | Chen et al. (2009a) |
| | | | |
IWP-3 | In vitro | PORCN protein | Inhibition of WNT secretion (WNT1, -2, and -3A?) | IC50: 40 nM | Chen et al. (2009a) |
| | | | |
IWP-4 | In vitro | PORCN protein | Inhibition of WNT secretion (WNT1, -2, and -3A?) | IC50: 25 nM | Chen et al. (2009a) |
| | | | |
IWP-L6 | In vitro | PORCN protein | Inhibition of WNT secretion | IC50: 0.5 nM | Wang et al. (2013b) |
LGK974 | In vitro | PORCN protein | Inhibition of WNT1, -2, -3, -3A, −6, -7A, and -9A secretion | IC50: 0.3–0.4 nM (depending on the cell assay) | Liu et al. (2013) |
ETC-159 | In vitro | PORCN protein | Inhibition of WNT1, -2, -3A, -6, -7B, −8A, -9A, -9B, and -10B secretion | IC50: 2.9 nM β-catenin reporter assay) | Madan et al. (2016a) |
| | | IC50: 18.1 nM (mouse PORCN inhibition) | |
WNT-C59 | In vitro and in vivo (mice) | PORCN protein | Inhibition of WNT1, -2, -3A, -6, -7B, −8A, -9A, -9B, and -10B secretion | IC50: 74 pM (WNT-3a-mediated | Proffitt et al. (2013) |
| | | TOPFLASH assay) | |
Compound 53 | In vitro | PORCN protein | Inhibition of WNT-3a secretion | IC50: 0.5 nM | Xu et al. (2016) |
4,4-DiOMEA | In vitro | PORCN protein? | Inhibition of WNT-16 secretion | IC50: 7.6 ± 1.5 nM | Ramirez de Molina et al. (2015) |