TABLE 1 

Summary of main molecular targets of hypnotic drugs

Mechanism-of-action details can be found in the text of this review, in review articles (Sanger, 2004; Wilson and Argyropoulos, 2005; Sills, 2006; Stahl, 2009), and/or in the summary of product characteristics for each individual drug.

Drug5-HT15-HT25-HT35-HT7α1α2MT1/MT2OX1/OX2H15-HTTNETD1D2D4m1Voltage-Gated Ca2+ ChannelsGABAA
RamelteonX
TasimelteonX
Melatonin prolonged-releaseX
AgomelatineXX
Low-dose doxepinXXX
SuvorexantX
TrazodoneXXXXX
AmitryptilineXXXXX
QuetiapineX*X*X*X*X*X*XX*
OlanzapineXXXXXXX
GabapentinX
PregabalinX
MirtazapineXXXXX
BenzodiazepinesX
Z-compoundsX
  • * Binding mainly due to its metabolite norquetiapine.