TABLE 1

Cluster of diseases with evidence of NRF2 association

Disease phenotypes with evidence of genetic association with NRF2 were selected from the DisGeNet database. DisGeNet integrates disease–gene association information from various resources, such as UniProt, ClinVar, GWAS Catalog, and Comparative Toxicogenomics Database and scores disease–gene associations according to the number of resources and publications supporting these associations. The curation of the list was based on the following criteria: 1) only pathophenotypes with more than one citation in Pubmed were selected; 2) the score of reliability was set to a threshold of 0.001; and 3) disease entries with very similar names or overlapping terms were simplified to one single entry.