Potential role of the polymorphisms of ADORA2A and adenosine deaminase genes in caffeine-related functions and caffeine consumption
More details can be found in the text.
Gene | Biologic Role | Clinical Relevance | Replication | Location in Text |
---|---|---|---|---|
ADORA2A | Anxiety | Modulation of anxiety levels in response to caffeine intake | Yes | IV.B.1.a |
Attention | Influence on attentional processing and working memory | Yes | IV.B.1.a | |
Emotional processing | Influence on startle reflex | Yes | IV.B.1.a | |
Maladaptive emotional processing | ||||
Impact on the selection of relevant early information | ||||
Panic disorder | Extreme reactions to stressful situations | Yes | IV.B.1.a | |
Agoraphobia | ||||
Sleep | Susceptibility to hyperarousal-induced insomnia | Yes | IV.B.1.b | |
Sleep latency | ||||
Modification of EEG sleep-linked characteristics | ||||
Caffeine consumption | Carrying the 1976TT genotype decreases caffeine consumption | No | IV.B.1.c | |
Adenosine deaminase | Sleep | Role in sleep architecture and maintenance | Yes | IV.B.1.b |
Controls the frequency of awakenings |