Model/Paradigm | Mouse | Rat | Cynomolgus Monkey |
---|---|---|---|
Schizophrenia positive symptoms | |||
Cocaine-induced LMAa–c | RO6017, RO3648, RO6390, RO3397 | RO3648 | |
L-687,414–induced LMAa–c | RO6017, RO3648, RO6390, RO3397 | ||
PCP-induced LMAc | RO6390, RO3397 | ||
DAT-KO (reduction of LMA)a,b | RO6017, RO3648 | ||
NR1-KD (reduction of LMA)a,b | RO3648 | ||
Schizophrenia cognitive symptoms | |||
Object retrievalb,c | RO3648, RO6390, RO3397 | ||
Attentional set-shiftingc | RO6390 | ||
Antidepression/stress-reducing | |||
Forced swim testb | RO3648, RO3397 | ||
Differential reinforcement of low-rate behaviorb,c | RO3648, RO6390, RO3397 | ||
Stress-induced hyperthermiaa,b | RO6017, RO3648 | ||
Wake-promotingc,d | RO3397 | RO3680, RO3397 | |
Antiaddiction | |||
Cocaine self-administrationb,e | RO3648, RO6390 | ||
Cocaine-ICSSe | RO6390, RO3397 | ||
Context-induced cocaine relapsef | RO3648, RO6390 | ||
Cocaine reward memoryg | RO6017 | ||
Abuse-related effects of cocaineh | RO3397 | ||
Abuse-related effects of methamphetaminei | RO3397 | ||
Methamphetamine self-administrationj | RO3648 | ||
Methamphetamine-induced impulsivityk | RO3397 | ||
Nicotine self-administration, nicotine-induced sensitization, reinstatement of nicotine seekingl | RO6017, RO3397 | ||
Morphine-induced sensitization, morphine self-administrationm | RO3397 | ||
Compulsive binge-like eatingn | RO6390 | ||
Antidiabetic | |||
oGTTo | RO6017 | ||
oGTT in diabetic db/db mice, DIO mice, and diet-induced obese Glp1R-KO miceo | RO6017 | ||
Gastric emptyingo | RO6017 | RO3397 | |
Reduction of weight gain and body weightc,o | RO6017 | RO3397 | |
Reduction of weight gain induced by antipsychotic olanzapinec | RO3397 | ||
No EPS liability (no effect on catalepsy)b,c | RO3648, RO6390, RO3397 | ||
Reduction of haloperidol-induced catalepsyb,c | RO3648, RO6390, RO3397 |
DIO, diet-induced obese; EPS, extrapyramidal side-effects; ICSS, intracranial self-stimulation; LMA, locomotor activity; oGTT, oral glucose tolerance test; RO3397, RO5263397; RO3648, RO5203648; RO6017, RO5166017; RO6390, RO5256390;.
↵a Revel et al. (2011).
↵b Revel et al. (2012b).
↵c Revel et al. (2013).
↵d Schwartz et al. (2017).
↵e Pei et al. (2015).
↵f Pei et al. (2014).
↵g Liu et al. (2016).
↵h Thorn et al. (2014a).
↵i Jing and Li (2015).
↵j Cotter et al. (2015).
↵k Xue et al. (2018).
↵l Liu et al. (2018).
↵m Liu et al. (2017a).
↵n Ferragud et al. (2017).
↵o Raab et al. (2015).