Functional activity (EC50) of endogenous and synthetic agonists of rat, mouse, human, and zebrafish olfactory TAARs

Mammalian TAARSpeciesLigandEC50
TAAR3Rat, mouseCyclohexylamine7 (mouse),b 20 (mouse)c
Isoamylamine10 (mouse)b,c
Octylamine50 (mouse)b
PEA 40 (mouse)b
TAAR4Rat, mousePEA0.7 (mouse),b 1 (mouse)c
TAAR5Human, rat, mouseTrimethylamine0.7 (mouse),b 0.3 (mouse),d 1 (rat),d 0.12 (human)e
N,N-dimethylethylamine1 (mouse),b 0.17 (human)e
N,N-dimethyloctylamine1 (mouse)b
N-methylpiperidine3 (mouse),b 20 (mouse),c >10 (human)e
Pyrrolidine17 (mouse)b
Triethylamine22 (mouse)b
3-pyrroline42 (mouse)b
2-methy-1-pyrroline46 (mouse)b
3ITa4.4 (human)f
TAAR7bRat, mouseN,N-dimethyloctylamine3 (mouse)b
N,N-dimethylbutylamine30 (mouse)b
TAAR7eRat, mouseOctylamine28 (mouse)b
Heptylamine34 (mouse)b
2-methy-1-pyrroline48 (mouse)b
TAAR7dRat, mouseN,N-dimethylcyclohexylamine0.5 (mouse)b
N-methylpiperidine16 (mouse)b
N,N-dimethylbutylamine30 (mouse)b
1-(2-aminoethyl)piperidine30 (mouse)b
Heptylamine33 (mouse)b
2-methy-1-pyrroline50 (mouse)b
TAAR8cHuman, rat, mouseN-methylpiperidine0.5 (rat)g
N,N-dimethylcyclohexylamine13 (rat)g
TAAR9Human, rat, mouseN-methylpiperidine18 (rat)g
N,N-dimethylcyclohexylamine27 (rat)g
Zebrafish TAARs
 TAAR13cZebrafishCadaverine20,i 10h
  • Only compounds with <50 μM activity are listed.

  • a Inverse agonist.

  • b Saraiva et al. (2016).

  • c Liberles and Buck (2006).

  • d Li et al. (2015).

  • e Wallrabenstein et al. (2013).

  • f Dinter et al. (2015c).

  • g Ferrero et al. (2012).

  • h Li et al. (2015).

  • i Hussain et al. (2013).