TABLE 3

Studies that have used repetitive TMS as a tool to cocaine or methamphetamine craving

This study performed 10 Hz TMS on the superior frontal gyrus and found an increase in craving but did not find a decrease in craving with 1 Hz to the superior frontal gyrus (L, left; R, right).

AuthorDrug of AbuseSample SizeSite of TMSFrequencySessionsBehavioral Effect?Active Sham Control
Camprodon et al. (2007)Cocaine6L/R DLPFC10 Hz1YesWithin subject
Hanlon et al. (2015b)Cocaine11L vMPFCcTBS6aYesWithin subject
Hanlon et al. (2017)Cocaine25L MPFCcTBS6aYesWithin subject
Politi et al. (2008)Cocaine36L DLPFC15 Hz10YesNo
Rapinesi et al. (2016)Cocaine7L DLPFCb20 Hz12YesBetween groups
Bolloni et al. (2016)Cocaine10Bilat PFC/Insb10 Hz12NoBetween groups
Terraneo et al. (2016)Cocaine32L DLPFC15 Hz>8YesNo
Li et al. (2013b)Meth.10L DLPFC1 Hz1 dayNoWithin subject
  • PFC, prefrontal cortex.

  • a Multiple sessions were given in a single day.

  • b Studies used H-coil TMS devices (Brainsway, Jerusalem, Israel). This deep TMS coil geometry has a very different field distribution than the typical figure of eight coils.