Studies that have used repetitive TMS as a tool to change nicotine craving

Multiple sessions were given in a single day. This study performed 10 Hz TMS on the superior frontal gyrus (SFG) and found an increase in craving but did not find a decrease in craving with 1 Hz to the SFG (L, left; R, right).

AuthorSample SizeSite of TMSFrequencySessionsBehavioral Effect?Active Sham Control
Amiaz et al. (2009)22L DLPFC10 Hz10 daysYesBetween groups
Dinur-Klein et al. (2014)115Bilat PFC/Insa10 Hz13YesBetween groups
Dinur-Klein et al. (2014)115Bilat PFC/Insa1 Hz13NoBetween groups
Eichhammer et al. (2003)14L DLPFC20 Hz4 daysNoWithin subject
Li et al. (2013a)16L DLPFC10 Hz2 daysYesWithin subject
Pripfl et al. (2014)14L DLPFC10 Hz1YesWithin subject
Rose et al. (2011)15SFG10 Hz3 daysYesWithin subject
Rose et al. (2011)15SFG1 Hz3 daysNoWithin subject
Trojak et al. (2015)37R DLPFC1 Hz10YesWithin subject
Sheffer et al. (2018)29L DLPFC20 Hz8YesWithin subject
Li et al. (2017)10L DLPFC10 Hz1YesWithin subject
  • PFC, prefrontal cortex.

  • a Studies used H-coil TMS devices (Brainsway, Jerusalem, Israel). This deep TMS coil geometry has a very different field distribution than the typical figure of eight coils.