Comparison of the relative reported intrinsic clearance (CLint, Vmax/Km) for CYP2B6*4 vs. CYP2B6*6
| Haplotype | System | CLint (% wild type) | Reference | Comments |
|---|---|---|---|---|
| 2B6*4 | E. coli | 170 | Bumpus et al. (2006) | N-terminally truncated transcripts |
| 2B6*4 | E. coli | 96 | Zhang et al. (2011) | N-terminally truncated transcripts |
| 2B6*4 | Sf9 cells | 142 | Ariyoshi et al. (2011) | |
| Avg ± S.E.M. | 136 ± 22 | |||
| 2B6*6 | HLM | 17 | Xu et al. (2012) | |
| 2B6*6 | UES | 53 | Xu et al. (2012) | No significant differences were observed in the presence or absence of cyt b and thus the CLint value is an average of the two measurements |
| 2B6*6 | E. coli | 20 | Zhang et al. (2011) | N-terminally truncated transcripts |
| 2B6*6 | Sf9 | 50 | Ariyoshi et al. (2011) | |
| 2B6*6 | COS-1 | 183 | Radloff et al. (2013) | |
| Avg ± S.E.M. | 65 ± 31 |
HLM, human liver microsomes from the specified haplotype; UES, unspecified expression system.