Mammalian anion channels: Classification and relation to cell volume and organic anion transport
| Species | Channel Name | Abbreviation | Molecule |
|---|---|---|---|
| Ligand gated | Glycine receptor | GlyR | GlyR |
| GABAA receptor | GABAAR | GABAA | |
| GABAC receptor | GABACR | GABAC | |
| Voltage gated | ClC-type chloride channel | ClC-1 | CLCN1 |
| ClC-2 (one of VAAC and VRAC) | CLCN2 | ||
| ClC-K1 | CLCNK1 | ||
| ClC-K2 | CLCNK2 | ||
| cAMP activated | Cystic fibrosis transmembrane conductance regulator | CFTR (one of VCAC and VSOAC) | CFTR |
| Ca2+ activated | CaCC (one of VCAC) | TMEM16A/ANO1 | |
| TMEM16B/ANO2 | |||
| TMEM16F/ANO6 | |||
| Volume activated | Volume-sensitive outwardly rectifying anion channel | VSOR (one of VAAC, VRAC,a and VSOAC) | LRRC8A+8C/8D/8E(+?c) |
| Maxi-anion channel | Maxi-Cl (one of VAAC, VRAC,a VSOAC, and MAC-1b) | SLCO2A1(+?c) | |
| Acid activated | Acid-sensitive outwardly rectifying anion channel | ASOR (one of VCAC) | ? |
↵a The VRAC abbreviation used in this work (for volume-regulated anion channel) is sometimes also referred to as the volume-regulatory anion channel.
↵b Maxi-Cl is the major type of maxi-anion channel (MAC-1) (see the text for details).
↵c The question mark represents some missing molecular component which may exist to reproduce a full set of phenotypes (see the text for details).