TABLE 1

 Mammalian anion channels: Classification and relation to cell volume and organic anion transport

SpeciesChannel NameAbbreviationMolecule
Ligand gatedGlycine receptorGlyRGlyR
GABAA receptorGABAARGABAA
GABAC receptorGABACRGABAC
Voltage gatedClC-type chloride channelClC-1CLCN1
ClC-2 (one of VAAC and VRAC)CLCN2
ClC-K1CLCNK1
ClC-K2CLCNK2
cAMP activatedCystic fibrosis transmembrane conductance regulatorCFTR (one of VCAC and VSOAC)CFTR
Ca2+ activatedCaCC (one of VCAC)TMEM16A/ANO1
TMEM16B/ANO2
TMEM16F/ANO6
Volume activatedVolume-sensitive outwardly rectifying anion channel VSOR (one of VAAC, VRAC,a and VSOAC)LRRC8A+8C/8D/8E(+?c)
Maxi-anion channelMaxi-Cl (one of VAAC, VRAC,a VSOAC, and MAC-1b)SLCO2A1(+?c)
Acid activatedAcid-sensitive outwardly rectifying anion channel ASOR (one of VCAC)?
  • a The VRAC abbreviation used in this work (for volume-regulated anion channel) is sometimes also referred to as the volume-regulatory anion channel.

  • b Maxi-Cl is the major type of maxi-anion channel (MAC-1) (see the text for details).

  • c The question mark represents some missing molecular component which may exist to reproduce a full set of phenotypes (see the text for details).