Chemical | ClC-2 | VSOR | Maxi-Cl | CFTR | CaCC | ASOR |
---|---|---|---|---|---|---|
Cd2+ | + | − | − | − | NS | − |
Gd3+ | − | −/+a | +∼+++ | − | − | − |
DCPIB | − | ++ | − | − | − | − |
DIDS (out) | − | ±∼++ VD | + | − | ±∼+ VD | ++∼+++ |
NPPB | ± VD | + | + | +++ VD | + | − |
NFA | − | ± | − | ± VD | +∼++ | + |
Glibenclamide | NS | ± (VDb) | − | +∼++ VD | + | ± |
Phloretin | NS | + | − | ± VD | − | + |
CFTRinh-172 | +++ VD | −/+∼++a | NS | +++ | − | NS |
CaCCinh-A01 | NS | − | NS | NS | ++ | NS |
T16Ainh-A01 | NS | −/++a | NS | NS | ++∼+++ | NS |
GaTx1 | − | NS | NS | +++ | − | NS |
GaTx2 | +++ | NS | NS | − | − | NS |
Methadone | +++ | NS | NS | − | NS | NS |
Insensitivity and sensitivity are denoted by minus and plus signs, respectively, as follows: −, insensitive; ±, sensitive at sub-millimolar (100 ≤ IC50 < 1000 μM) concentrations; +, sensitive at deca-micromolar (10 ≤ IC50 < 100 μM) concentrations; ++, sensitive at micromolar (1 ≤ IC50 < 10 μM) concentrations; and +++, sensitive at sub-micromolar (IC50 < 1 μM) concentrations. NS, not studied; VD, voltage-dependent block.
↵a Depending on cell type (see the text for details).
↵b Voltage-dependent block only by the charged form.