TABLE 2

 Pharmacological distinctions among VAACs and VCACs

ChemicalClC-2VSORMaxi-ClCFTRCaCCASOR
Cd2++NS
Gd3+−/+a+∼+++
DCPIB++
DIDS (out)±∼++ VD+±∼+ VD++∼+++
NPPB± VD+++++ VD+
NFA±± VD+∼+++
GlibenclamideNS± (VDb)+∼++ VD+±
PhloretinNS+± VD+
CFTRinh-172+++ VD−/+∼++aNS+++NS
CaCCinh-A01NSNSNS++NS
T16Ainh-A01NS−/++aNSNS++∼+++NS
GaTx1NSNS+++NS
GaTx2+++NSNSNS
Methadone+++NSNSNSNS
  • Insensitivity and sensitivity are denoted by minus and plus signs, respectively, as follows: −, insensitive; ±, sensitive at sub-millimolar (100 ≤ IC50 < 1000 μM) concentrations; +, sensitive at deca-micromolar (10 ≤ IC50 < 100 μM) concentrations; ++, sensitive at micromolar (1 ≤ IC50 < 10 μM) concentrations; and +++, sensitive at sub-micromolar (IC50 < 1 μM) concentrations. NS, not studied; VD, voltage-dependent block.

  • a Depending on cell type (see the text for details).

  • b Voltage-dependent block only by the charged form.