Information about study length, washout profile, dose schedule, route, and nutritional conditions
Number of saline control animals appears within parentheses.
| Treatment | Study | Protocol | Route | Lean Rats | Obese Rats |
|---|---|---|---|---|---|
| Acute | On-off 1 h | 1 h infusion | i.v. | 4 (3) | 5 (3) |
| On-off 5 h | 5 h infusion | s.c. | 7 (2) | 7 (5) | |
| On-off 12 h | 12 h infusion | s.c. | 5 (2) | 4 (2) | |
| Step-down 1 h | 1 h infusion plus 3.5 h of step-down infusion | i.v. | 5 (2) | 5 (2) | |
| Step-down 12 h | 12 h infusion plus 3.5 h of step-down infusion | s.c. | 5 (3) | 4 (3) | |
| Semichronic | Continuous 120 h | 120 h pretreatment infusion plus 5 h infusion | s.c. | 6 (2) | 8 (2) |
| Intermittent 120 h | 120 h pretreatment intermittent infusion (12 h infusion plus 12 h washout) plus 5 h infusion | s.c. | 6 (2) | 8 (3) |