Outstanding questions in pharmacomicrobiomics
| Key Questions |
|---|
| Do disease-associated microbiomes impact on bacterial enzyme expression and/or activity to dysregulate xenobiotic metabolism? |
| What is the impact of extreme of life microbiome variation on pharmacokinetics and pharmacodynamics? |
| Can we unravel disease vs. drug-induced contributions to microbiome alterations? |
| Can the use of microbiome composition to predict therapeutic response be incorporated into clinical practice? |
| Can we identify bacteria- and/or enzyme-specific host–microbe interactions for subsequent therapeutic targeting? |
| Can we compile and systematically evaluate currently unexplained aberrant pharmacokinetic observations? |
| Can diet be used to beneficially tune microbial xenobiotic metabolism? |
| Can we differentiate between effects of acute and long-term exposure to xenobiotics on the gut microbiome? |
| Should we re-evaluate the guidelines for coadministration of antibiotics? |