TABLE 5

Purinergic receptor ligands in clinical studies for treating inflammatory diseases

DrugTargetAgonist or AntagonistDiseaseStatusCompanyReferences
CE-224,535P2X7AntagonistRheumatoid arthritisPhase 2PfizerNCT00628095
GSK1482160P2X7AntagonistInflammatory pain (arthritis)Phase 1Glaxo SmithKlineNCT00849134
PBF-680A1AntagonistAsthmaPhase 1PalabiofarmaNCT01845181
PBF-680A1AntagonistAsthmaPhase 2PalabiofarmaNCT02635945
UK 432097A2AAgonistCOPDPhase 2PfizerNCT00430300
PoclidenosonA3AgonistRheumatoid arthritisPhase 3CanFite PharmaNCT02647762
PoclidenosonA3AgonistPsoriasisPhase 3CanFite PharmaNCT00428974
PBF-677A3AgonistUlcerative colitisPhase 2PalabiofarmaNCT02639975