Studies examining the effects of MDMA on fear-motivated learning and memory
Article | Taska | Subjectsb | Doses/Frequencyc | Timelined | Effectse |
---|---|---|---|---|---|
Moyano et al., 2004 | PA | Rats (W), Adult, Male | 10 mg/kg (i.p.) × 1 | Training: On-Drug Testing: Postdrug | ↓ |
Moyano et al., 2005 | PA | Rats (W), Adult, Male | 10 mg/kg (i.p.) × 1 AND/OR × 2/day, 4 days | Training: On-Drug (Single), Postdrug (Repeated) Testing: Postdrug | ↓ (Single) ⌀ (Repeated) |
Barrionuevo et al., 2000 | PA | Rats (W), Adult, Male | 20 mg/kg (i.p.) × 1 | Training: On-Drug Testing: Postdrug | ↓ |
Budzynska et al., 2017 | PA | Mice (SW), Adult, Male | 1, 2.5, 5, or 10 mg/kg (i.p.) × 1 | Training: Off-Drug2 Testing: Postdrug | ↑ (2.5 and 5 mg/kg) ⌀ (1 and 10 mg/kg) |
Shariati et al., 2014 | PA | Rats (W), Adult, Male | 10 mg/kg (i.p.) × 1 OR × 1/day, 2 day/wk, 3 wk | Training: Off-Drug2 Testing: Postdrug | ↓ |
Jahanshahi et al., 2013 | PA | Rats (W), Adult, Male | 2.5, 5, or 10 mg/kg (i.p.) × 3/day, 1 day/wk, 4 wk | Training: Predrug Testing: Postdrug | ↑ |
Timár et al., 2003 | PA | Rats (W), Adol., Male | 10 mg/kg (s.c.) × 4 | Training/Testing: Postdrug | ⌀ |
Murnane et al., 2012 | PA | Mice (SW), Adol., Male | 10 or 20 mg/kg (i.p.) × 4 | Training/Testing: Postdrug | ⌀ |
García-Pardo et al., 2015 | PA | Mice (OF1), Adol., Male | 10 mg/kg (i.p.) × 1/day, 4 days (spaced) | Training/Testing: Postdrug | ↓ |
García-Pardo et al., 2017 | PA | Mice (OF1), Adol., Male | 10 mg/kg (i.p.) × 1/day, 4 days (spaced) | Training/Testing: Postdrug | ↓ |
Rodríguez-Arias et al., 2011 | PA | Mice (OF1), Adol., Male | 10 or 20 mg/kg (i.p.) × 2/day, 2 days/wk, 2 wk | Training/Testing: Postdrug | ⌀ |
McNamara et al., 1995 | PA | Rats (SD), Adult, Male | 5, 10, or 20 mg/kg (i.p.) × 2/day, 4 days | Testing: Postdrug | ⌀ |
Shortall et al., 2013 | FC | Rats (LH), Adult, Male | 10 mg/kg (i.p.) × 1/day, 3 days (spaced) | Training: Off-Drug2 Testing: Postdrug | ⌀ |
Johansson et al., 2015 | FC | Mice (ICR), Adult, Male | 20 mg/kg (i.p.) × 2 | Training/Testing: Postdrug | ↓ |
↵a Studies used the passive avoidance (PA) and contextual fear conditioning (FC) tasks.
↵b Species (strain), age, and sex of subjects. Strains include Lister Hooded (LH), Sprague-Dawley (SD), and Wistar (W) rats; and ICR, OF1, and Swiss Webster (SW) mice.
↵c Dose, route, and frequency of MDMA administration. Treatment days/weeks are consecutive unless noted as “spaced.”
↵d When training and testing occurred in relation to drug treatment. Pre- and post-drug training/testing were always conducted off-drug.
↵e Effects of drug treatment on learning and memory: ⌀ No Effect, ↓ Impairment, ↑ Enhancement.
2 Off-drug training/testing took place immediately before drug administration on (last) day of treatment.