TABLE 1

Basic physicochemical properties of the halogenated ethers

Halogenated Ether	Clinical Introduction (US)	Boiling Point (°C)	Vapor Pressure (mmHg 20°C)	MAC % (Age 30–55, 1 atm)	Blood/Gas Partition Coefficient (37°C)	Oil/Gas Partition Coefficient (37°C)	EC₅₀ (mM)
Fluroxene	1954	43.2	286	3.4	1.37	47.7	—
Methoxyflurane	1960	105	22.5	0.2	12	950	0.27^a
Enflurane	1972	57	172	1.63	1.9	99	0.49^b
Isoflurane	1981	48	240	1.17	1.4	90.8	0.27^b
Desflurane	1992	23	669	6	0.45	19	0.53^b
Sevoflurane	1995	59	170	2	0.65	47–54	0.30^b

Values for fluroxene obtained from Morris (1972). All other physicochemical property values obtained from Miller et al. (2015) or Lavelle and Kurra (2017). EC₅₀ values in human obtained from
↵^a Franks and Lieb (1993),
↵^b Franks and Lieb (1996). atm, atmosphere.