TABLE 2

Expression of apelin receptor (APLNR), apelin, and ELA in mouse, rat, and human tissues

Compiled from Edinger et al. (1998), Hosoya et al. (2000), Lee et al. (2000), O’Carroll et al. (2000), Medhurst et al. (2003), Kleinz and Davenport (2005), Regard et al. (2008), Pope et al. (2012), Deng et al. (2015), Wang et al. (2015b).

	APLNR			Apelin			ELA
	Human	Rat	Mouse	Human	Rat	Mouse	Human	Rat	Mouse
Brain	+++	++	+	++	+	+++
-paraventricular nucleus		+	++
-supraoptic nucleus		++	++
Anterior pituitary	+^{^a}	+++	+++	++^{^a}	+^{^a}
Intermediate pituitary		−/+	−/+		+/+++
Posterior pituitary		−/+	−/++		+/++
Thymus	+	−	+			−
Spinal cord	+	+++	++	++	++
Cerebellum	+	+	−	+	+	−
Hippocampus	+	+	−	+	+
Thalamus	+	+		+	+
Heart	+	++	+++	+	++	++	−/+	+
Adrenal gland		+	+		+
Lungs	++	+++	++	+	+++	++	+
Stomach	+	+	+	−	+
Liver	+	−	+	−	−	−
Small intestine	++	+	+	−	+
Large intestine	++	+	+		+
Pancreas	+	−	+	+
Kidney	+	+	+	+	+	+	++	+++
Testis	+	+	+	+	+	++
Prostate	+			+			++
Ovary	+	+	++		+	+
Uterus	+	+	++	−	+	−
Placenta	++	++		++
Mammary gland		+			++
Skeletal muscle	+	++	++	−	+	+
Adipose tissue	++	++	++^{^b}		++
Cartilage	++	++
Spleen	+++	−	+		−	+
Skin		+	+
Bladder		+	+
Gall bladder			+

+++, high expression; ++, moderate expression; low expression; −, absence mRNA expression.
↵^a Expression in whole pituitary gland.
↵^b Expression reported in both white and brown adipose tissue.