Enhance infrastructure | | | | |
| Monoamine neurotransmitter systems | To optimize the balance in 5-HT, dopamine, and norepinephrine neurotransmission | Facilitation of SMS shifts from arousal to satiety | V.B.1 |
| Circadian rhythmicity | To maximize entrainment and synchrony of oscillatory processes | Reliance of SMS on well coordinated circadian processes | V.B.2 |
| NAD metabolism | To optimize a wide range of cellular functions | Reliance of SMS on efficient cellular functioning | V.B.3 |
Facilitate relearning | | | | |
| SMS module for Appraisal of Potential Danger | To facilitate relearning of appraisal of potential danger | Augmentation of neural plasticity to aid recalibration of SMS | V.C |
| SMS output modules | To facilitate relearning of behavioral response repertoire | Augmentation of neural plasticity and provision of enhanced affective cues for SMS shut down | V.C |
Fix a weak link | | | | |
| 5-HT signaling via 5-HT2C receptors | To restore negative feedback yedasentience signaling that shuts down SMS | Increase of serotonergic-mediated satiety | V.D.2.a |
| SMS-neuroimmune communication | To use microglia “off” signaling molecules to shut down SMS | SMS negative feedback pathways employ same transmitters as microglia “off” signals | V.D.2.b |