Compounds enhancing ABCA1 and ABCG1 mRNA stability

Overview of compounds that enhance ABCA1 and ABCG1 mRNA stability, including their primary pharmacological action, effects on ABCA1 and ABCG1 expression (arrows: mRNA, protein), and effects on cellular cholesterol efflux. Effects on ABCA1, ABCG1, and cholesterol efflux are presented as follows: (↓) decreased; (= ) no effect; (↑) increased. Italicized symbols indicate changes in ABCA1 and ABCG1 mRNA levels, whereas nonitalicized symbols indicate protein levels.

CompoundPrimary ActionABCA1ABCG1Cholesterol EffluxReference
AICARAMPK agonist==J774.A1J774.A1J774.A1Li et al., 2010; Kemmerer et al., 2016
A769662Allosteric AMPK agonistTHP-1J774.A1THP-1Li et al., 2010; Kemmerer et al., 2016
SalicylateAllosteric AMPK agonistTHP-1Kemmerer et al., 2016
  • a apoE−/− C75BL/6 mice.

  • PM, peritoneal macrophages.