Compounds enhancing ABCA1 and ABCG1 mRNA stability
Overview of compounds that enhance ABCA1 and ABCG1 mRNA stability, including their primary pharmacological action, effects on ABCA1 and ABCG1 expression (arrows: mRNA, protein), and effects on cellular cholesterol efflux. Effects on ABCA1, ABCG1, and cholesterol efflux are presented as follows: (↓) decreased; (= ) no effect; (↑) increased. Italicized symbols indicate changes in ABCA1 and ABCG1 mRNA levels, whereas nonitalicized symbols indicate protein levels.
| Compound | Primary Action | ABCA1 | ABCG1 | Cholesterol Efflux | Reference | |||
|---|---|---|---|---|---|---|---|---|
| AICAR | AMPK agonist | == | J774.A1 | ↑↑ | J774.A1 | J774.A1 | Li et al., 2010; Kemmerer et al., 2016 | |
| ↑ | THP-1 | ↑↑ | PMa | ↑ | HDL | |||
| A769662 | Allosteric AMPK agonist | ↑↑ | THP-1 | ↑ | J774.A1 | ↑ | THP-1 | Li et al., 2010; Kemmerer et al., 2016 |
| Salicylate | Allosteric AMPK agonist | ↑ | THP-1 | — | — | Kemmerer et al., 2016 | ||
↵a apoE−/− C75BL/6 mice.
PM, peritoneal macrophages.