Compounds increasing ABCA1/G1 expression or function by an unknown mechanism
Overview of compounds that increase ABCA1 or ABCG1 expression or function by a yet unknown mechanism, including their primary pharmacological action, effects on ABCA1 and ABCG1 expression (arrows: mRNA, protein), and effects on cellular cholesterol efflux. Effects on ABCA1, ABCG1, and cholesterol efflux are presented as follows: (↓) decreased; (= ) no effect; (↑) increased. Italicized symbols indicate changes in ABCA1 and ABCG1 mRNA levels, whereas nonitalicized symbols indicate protein levels.
Compound | Primary Action | ABCA1 | ABCG1 | Cholesterol Efflux | Reference | |||
---|---|---|---|---|---|---|---|---|
1-Phenyl-2-Decanoylamino-3-morpholino-1-propanol | Glycosylceramide transferase inhibitor | ↑↑ | Skin fibroblastsa | — | ↑ | Skin fibroblastsa | Glaros et al., 2005 | |
↑ | MDMa | |||||||
Aclarubicin | Topoisomerase I and II inhibitor | ↑↑ | HepG2 | — | — | Gao et al., 2008 | ||
Anacetrapib | CETP inhibitor | — | — | ↑ | THP-1 | Yvan-Charvet et al., 2010a; Brodeur et al., 2017 | ||
↑ | BHK | |||||||
↑ | ABCA1-expressing BHK | |||||||
Daidzein | Mitochondrial aldehyde dehydrogenase inhibitor | ↑↑ | HepG2 | — | — | Gao et al., 2008 | ||
Dalcetrapib | CETP inhibitor | — | — | ↑ | BHK | Brodeur et al., 2017 | ||
↑ | ABCA1-expressing BHK | |||||||
Ibrutinib | NLRP3 inflammasome inhibitor | ↑ | THP-1 | = | THP-1 | THP-1 | Chen et al., 2018 | |
= | apoA-I | |||||||
↑ | HDL | |||||||
IMB2026791 | Unknown | — | — | ↑ | THP-1 | Liu et al., 2012 | ||
↑ | CHO-ABCA1 | |||||||
↑ | CHO | |||||||
MCC950 | NLRP3 inflammasome inhibitor | ↑ | THP-1 | = | THP-1 | THP-1 | Chen et al., 2018 | |
= | apoA-I | |||||||
↑ | HDL | |||||||
Metformin | Antihyperglycemic agent | == | RAW264.7 | ↑↑ | RAW264.7 | RAW264.7 | He et al., 2019 | |
= | apoA-I | |||||||
↑ | HDL | |||||||
N-butyldeoxynojirimycin | Glycosylceramide transferase inhibitor | — | — | = | Skin fibroblastsa | Glaros et al., 2005 | ||
Pratensein | Unknown | ↑↑ | HepG2 | — | — | Gao et al., 2008 | ||
Pyrromycin | Microbial protein synthesis inhbitor | ↑↑ | HepG2 | — | — | Gao et al., 2008 | ||
t-AUCB | Soluble epoxide hydrolase inhibitor | ↑↑ | Liverb | == | Liverb | ↑ | 3T3-L1 adipocytes | Shen et al., 2015 |
↑ | Epididymal fatc | |||||||
↑ | RCTb | |||||||
Torcetrapib | CEPT inhibitor | ↑ | THP-1 | ↑ | THP-1 | Yvan-Charvet et al., 2007 |