Transporter (Modeled Conformation) | Crystallized Model Transporter (Conformational) | Homology a.a. Identity (a.a. Similarity) | Procedure | References |
---|---|---|---|---|
rOCT1 (i-open) | Lactose permease LacY from E. coli (i-open) | 14.8% (23.0%) | Crystal structure–based homology modeling | Abramson et al., 2003; Popp et al., 2005 |
rOCT1 (o-open) | Based on prediction of structural changes of modeled i-open state | Volk et al., 2009 | ||
hOCT1 (i-open) | Glycerol-3-phosphate transporter GlpT from E. coli (i-open) | 15.0% (25.5%) | Crystal structure–based homology modeling | Huang et al., 2003; Boxberger et al., 2018 |
hOCT1 (o-open) | Several members of the MFS | Integrative combinational modeling | Roy et al., 2010; Dakal et al., 2017 | |
rOCT2 (i-open) | LacY from E. coli (i-open) | 14.0% (24.0%) | Crystal structure–based homology modeling | Abramson et al., 2003; Schmitt et al., 2009 |
rabbit OCT2 (i-open) | Lactose permease LacY and glycerol-3-phosphate transporter GlpT from E. coli (i-open) | 14.4% (22.3%) 10.5% (20.0%) | Crystal structure–based homology modeling | Abramson et al., 2003; Huang et al., 2003; Zhang et al., 2005 |
hOCT2 (i-open) | Lactose permease LacY and glycerol-3-phosphate transporter GlpT from E. coli (i-open) | 13.4% (23.2%) 14.6% (26.2%) | Crystal structure–based homology modeling | Abramson et al., 2003; Huang et al., 2003; Pelis et al., 2006 |
hOCT3 (i-open) | Glycerol-3-phosphate transporter GlpT from E. coli (i-open) | 15.3% (26.4%) | Crystal structure–based homology modeling | Huang et al., 2003; Chen et al., 2010a |
mOCT3 (o-open) | Human glucose transporter GLUT3 (o-occ) | 19.5% (34.2%) | Crystal structure–based homology modeling | Deng et al., 2015; Song et al., 2019 |
hMATE2-K (o-open) | MATE transporter NorM from vibrio cholerae (o-open) | 17.6% (34.4%) | Crystal structure–based homology modeling | He et al., 2010; Choi et al., 2011 |
a.a, amino acid; i-open, inward open conformation; o-occ, outward occluded conformation; o-open, outward open conformation.