TABLE 1

Model substrates of human organic cation transporters

Charge of major microspecies at pH 7.4 was calculated with program MarvinSketch version 19.3 of ChemAxon (https://chemaxon.com/products/marvin). ASP: Biermann et al., 2006; Grigat et al., 2009; Ahlin et al., 2011; Kido et al., 2011; Wittwer et al., 2013; Chen et al., 2017a; Sandoval et al., 2018, DAPI (4′,6-diamidino-2-phenylindole): Yasujima et al., 2010, 2011, fluoro-L-α-methyltyrosine: Wei et al., 2016, fluoromethylcholine: Visentin et al., 2017b, 2018, MPP: Gorboulev et al., 1997; Zhang et al., 1997; Ohashi et al., 1999; Wu et al., 2000; Bednarczyk et al., 2003; Gründemann et al., 2003; Otsuka et al., 2005; Sata et al., 2005; Masuda et al., 2006; Tanihara et al., 2007; Lee et al., 2009; Zolk et al., 2009a; Astorga et al., 2012; Belzer et al., 2013; Bexten et al., 2015; Lechner et al., 2016; Martínez-Guerrero et al., 2016, NBD-MTMA: Belzer et al., 2013; Martínez-Guerrero and Wright, 2013; Martínez-Guerrero et al., 2016; Sandoval et al., 2018, N-metyl-quinidine: Van Montfoort et al., 2001, rhodamine 123: Jouan et al., 2014; Lechner et al., 2016, TEA: Gorboulev et al., 1997; Zhang et al., 1997; Tamai et al., 1998; Ohashi et al., 2002; Bednarczyk et al., 2003; Peltekova et al., 2004; Bourdet et al., 2005; Otsuka et al., 2005; Masuda et al., 2006; Geier et al., 2007; Tanihara et al., 2007; Umehara et al., 2007; Cheng et al., 2009; Ming et al., 2009; Ohta et al., 2009; Astorga et al., 2012; Belzer et al., 2013; Hendrickx et al., 2013; Sandoval et al., 2018.