Compound (Charge of Major Microspecies at pH 7.4) Function | Apparent Km (IC50) [µM] | ||||
---|---|---|---|---|---|
hOCT1 | hOCT2 | hOCT3 | hMATE1 | hMATE2-K | |
Aflatoxin (0) mycotoxin | t (64) | t (121) | |||
Ethidium (+) mutagenic | 0.8 | 1.7 | 2 | ||
Monocrotaline (+) pneumotoxic | 25 (5.5) | ||||
Paraquat (++) toxic herbicide | t | 114 | n.t.d. | 169a, 212a (51a) | (16a) |
n.t.d. no transport detected; t, transported.
↵a Uptake measurements performed in presence of an outwardly directed proton gradient.