TABLE 6

Abundance of mRNA and protein of human organic cation transporters in various organs, tissues, and cells

The degree of expression of mRNA (crosses) is estimated from observations reported in the literature. The related references are indicated in normal face. Due to partially differing results, only an arbitrary classification could be performed. Detection of protein by Western blotting, immunohistochemistry, or proteomics is indicated by asterisks. The related references are indicated in italics when only protein expression was investigated and in underlined normal face when both mRNA and protein were not determined. The clasification has been performed on the basis of the following publications: hOCT1: Gorboulev et al., 1997; Pietig et al., 2001; Alcorn et al., 2002; Motohashi et al., 2002; Bottalico et al., 2004, 2007; Lips et al., 2005, 2007; Nishimura and Naito, 2005; Ballestero et al., 2006; Hilgendorf et al., 2007; Meier et al., 2007; Minuesa et al., 2008; Okabe et al., 2008; Zhang et al., 2008; Nies et al., 2009; Tzvetkov et al., 2009; Moreno-Navarrete et al., 2011; Gupta et al., 2012; Geier et al., 2013; Han et al., 2013; Drozdzik et al., 2014, 2019; Bexten et al., 2015; Cai et al., 2016; Arner et al., 2018; Breining et al., 2018, skin: K. Lips and H. Koepsell, unpublished data, hOCT2: Gorboulev et al., 1997; Busch et al., 1998; Pietig et al., 2001; Alcorn et al., 2002; Motohashi et al., 2002; Bottalico et al., 2004, 2007; Lips et al., 2005, 2007; Nishimura and Naito, 2005; Hilgendorf et al., 2007; Minuesa et al., 2008; Okabe et al., 2008; Filipski et al., 2009; Moreno-Navarrete et al., 2011; Bschleipfer et al., 2012; Geier et al., 2013; Sprowl et al., 2013; Bexten et al., 2015; Cai et al., 2016; Arner et al., 2018; Breining et al., 2018; Dolberg and Reichl, 2018, skin: K. Lips and H. Koepsell, unpublished data, hOCT3: Wu et al., 2000; Motohashi et al., 2002; Bottalico et al., 2004, 2007; Lips et al., 2005, 2007; Müller et al., 2005; Nishimura and Naito, 2005; Sata et al., 2005; Hilgendorf et al., 2007; Minuesa et al., 2008; Okabe et al., 2008; Nies et al., 2009; Duang and Wang, 2010; Solbach et al., 2011; Bschleipfer et al., 2012; Geier et al., 2013; Lee et al., 2014a; Bexten et al., 2015; Cai et al., 2016; Arner et al., 2018; Breining et al., 2018; Drozdzik et al., 2019; Song et al., 2019, skin: K. Lips and H. Koepsell, unpublished data, hOCTN1: Tamai et al., 1997; Pietig et al., 2001; Alcorn et al., 2002; Motohashi et al., 2002; Tokuhiro et al., 2003; Xuan et al., 2003; Kobayashi et al., 2004; Peltekova et al., 2004; Gründemann et al., 2005; Nishimura and Naito, 2005; Hiasa et al., 2006; Bottalico et al., 2007; Hilgendorf et al., 2007; Horvath et al., 2007; Meier et al., 2007; Minuesa et al., 2008; Okabe et al., 2008; Grigat et al., 2009; Markova et al., 2009; McBride et al., 2009; Sugiura et al., 2010; Bexten et al., 2015; Visentin et al., 2017b; Arner et al., 2018; Berg et al., 2018; Dolberg and Reichl, 2018, hOCTN2: Tamai et al., 1998; Wu et al., 1998b; Pietig et al., 2001; Motohashi et al., 2002; Tokuhiro et al., 2003; Xuan et al., 2003; Peltekova et al., 2004; Nishimura and Naito, 2005; Grube et al., 2006; Hilgendorf et al., 2007; Horvath et al., 2007; Meier et al., 2007; Minuesa et al., 2008; Okabe et al., 2008; Grigat et al., 2009; Geier et al., 2013; Bexten et al., 2015; Mooij et al., 2016; Berg et al., 2018; Dolberg and Reichl, 2018, hMATE1: Otsuka et al., 2005; Masuda et al., 2006; Tanihara et al., 2007; Ahmadimoghaddam et al., 2013; Geier et al., 2013; Motohashi et al., 2013; Bexten et al., 2015; Cai et al., 2016; Nies et al., 2016; Arner et al., 2018; Berg et al., 2018; Breining et al., 2018; Drozdzik et al., 2019, hMATE2-K: Masuda et al., 2006; Tanihara et al., 2007; Geier et al., 2013; Motohashi et al., 2013; Cai et al., 2016; Arner et al., 2018.