TABLE 7

Expression of human organic cation transporters in tumors in different organs detected on mRNA and/or protein level

hOCT1: Kantarjian et al., 2004; Ballestero et al., 2006; Zhang et al., 2006; Monks et al., 2007; Wang et al., 2008; Schaeffeler et al., 2011; Heise et al., 2012; Herraez et al., 2013; Lin et al., 2013; Cai et al., 2016; Visentin et al., 2017b; Al-Abdulla et al., 2019, hOCT2: Rhodes et al., 2004; Zhang et al., 2006; Monks et al., 2007; Filipski et al., 2009; Burger et al., 2010; Lin et al., 2013; Cai et al., 2016; Liu et al., 2016b; Visentin et al., 2018, hOCT3: Rhodes et al., 2004; True et al., 2006; Monks et al., 2007; Tomlins et al., 2007; Wang et al., 2007; Eeles et al., 2008; Yokoo et al., 2008; Cui et al., 2011; Schaeffeler et al., 2011; Heise et al., 2012; Lin et al., 2013; Cai et al., 2016; Hu et al., 2018, hOCTN1: Rhodes et al., 2004; Monks et al., 2007; Wang et al., 2007; Drenberg et al., 2017; Visentin et al., 2017b; Hu et al., 2018, hOCTN2: Rhodes et al., 2004; Monks et al., 2007; Wang et al., 2007; Fink et al., 2019, MATE1: Cai et al., 2016, hMATE2-K: Cai et al., 2016; Liu et al., 2016b.

Cancerous Tissue, LocalizationhOCT1hOCT2hOCT3hOCTN1hOCTN2MATE1hMATE2-K
Breast cancer++++, d+++
Buccal squamosal cell carcinoma+, i
Colon cancer+, s+, i+, i
Cholangiocarcinoma+, d
Glioblastoma+, i
Hepatocellular carcinoma+, d+, s, d+, i
Lung non-small cell carcinoma+, s+, d+, s, d+, s, d+, s
Myeloic leukemia++
Esophageal cancer+, s+, s+, s
Ovary cancer(+)+, d
Prostate cancer(+)+, d
Rectal cancer+, i
Renal cell carcinoma+, d+, s+, d++, d
Stomach cancer+, i
Uterin cancer+, d
  • +, expression; (+), probable expression; d, decreased expression in tumor versus respective organ; i, increased expression in tumor versus respective organ; s, similar expression in tumor and respective organ.