Negative allosteric modulators of neuronal nAChRs and studies investigating them as pharmacotherapies for tobacco use disorder
| Drug | nAChR subtype activity | Characterized in vitro? | In vivo findings | References |
|---|---|---|---|---|
| UCI-30002 | Full activity at α7 and α3β4, partial activity at α4β2 | Yes | Diminishes nicotine self-administration in rats | Yoshimura et al., 2007 |
| KAB-18 | Selective activity at α4β2 | Yes | N.A. | Henderson et al., 2010 |
| DB04763 | Selective activity at α7 | Yes | N.A. | Smelt et al., 2018 |
| DB08122 | Selective activity at α7 | Yes | N.A. | Smelt et al., 2018 |
| Pefloxacin | Selective activity at α7 | Yes | N.A. | Smelt et al., 2018 |
N.A., not applicable.