Summary of findings in cell-specific STAT3–KO mice

STAT3 KO in CellPhenotypeReference
All cellsEmbryonic lethal at 7 daysTakeda et al., 1997
KeratinocytesImpaired hair cycle and skin wound healingSano et al., 1999
Respiratory epitheliumImpaired injury toleranceHokuto et al., 2004
Intestinal epitheliumImpaired epithelial wound healingPickert et al., 2009
CardiomyocyteIncreased presbycardia and MI susceptibilityJacoby et al., 2003; Hilfiker-Kleiner et al., 2004
HepatocytesInsulin resistance; impaired liver regenerationInoue et al., 2004; Moh et al., 2007
AdipocyteIncreased body weight and adiposityCernkovich et al., 2008
Neural cellsObesity, diabetes, infertility, and thermal dysregulationGao et al., 2004
Hematopoietic progenitorsUnaltered basal hematopoiesis; impaired stem cell regeneration after 5-FULee et al., 2002; Chung et al., 2006
Hematopoietic-derived cellsImpaired DC function: defective transition of CMP/CLP to common DC precursorsLaouar et al., 2003
Bone marrow cellsImpaired myeloid cells resulting in Crohn’s disease-like pathologyWelte et al., 2003
T cellsIncreased apoptosis and impaired Th17 developmentTakeda et al., 1998b; Yang et al., 2007b
B cellsReduced B cell compartments and plasma cellsChou et al., 2006; Fornek et al., 2006
Macrophages and neutrophilsHigh susceptibility to endotoxin shock, ↑ TNF-α, IL-1, and IFN-γTakeda et al., 1999
  • CLP, common lymphoid progenitor; 5-FU, fluorouracil.